Agent Name

Phosphorus pentachloride

CAS Number

10026-13-8

Formula

Cl5-P

Major Category

Toxic Gases & Vapors

Synonyms

Fosforo(pentacloruro di) [Italian]; Fosforpentachloride [Dutch]; Pentachlorophosphorane; Phosphorane, pentachloro-; Phosphore(pentachlorure de) [French]; Phosphoric chloride; Phosphoric perchloride; Phosphorous pentachloride; Phosphorpentachlorid [German]; Phosphorus chloride (PCl5); Phosphorus perchloride; Phosphorus(V) chloride; Pieciochlorek fosforu [Polish]; [ChemIDplus] UN1806

Category

Other Toxic Gases & Vapors

Description

Greenish-yellow crystalline solid with an irritating odor; [CAMEO]

Sources/Uses

Used as a catalyst, chlorinating agent in chemical synthesis, dehydrating agent, and in aluminum metallurgy; [ACGIH]

Comments

Eye irritation and acute bronchitis have been reported after occupational exposures. Hydrogen chloride is released upon contact with water. [ACGIH] Toxic to the liver in chronic animal studies; [Desai, H. Phosphorus and Phosphorus Compounds. In: Sullivan J, Krieger G (eds).Hazardous Materials Toxicology.Baltimore:Williams & Wilkins,1992;939] A corrosive substance that can cause pulmonary edema; [ICSC]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

Dangerous When Wet

Yes - A material that, by contact with water, is liable to become spontaneously flammable or to give off flammable or toxic gas at a rate greater than 1 L per kilogram of the material, per hour; [ERG 2004]

TLV (ACGIH)

0.85 mg/m3

PEL (OSHA)

1 mg/m3

MAK

1 mg/m3, inhalable fraction

IDLH (NIOSH)

70 mg/m3

Excerpts from Documentation for IDLHs

Other data: The vapors of phosphorus pentachloride decompose in the presence of moisture with the subsequent liberation of hydrochloric and phosphoric acids [Henderson and Haggard 1943].

Vapor Pressure

0.01 mm Hg

Lethal Concentration

LC50 (rat) = 205 mg/m3

Reference Link

ICSC: Phosphorus pentachloride

Adverse Effects
Toxic Pneumonitis

Yes

Hepatotoxin

Hepatotoxin, Secondary

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: