Agent Name

Streptozocin

CAS Number

18883-66-4

Formula

C8-H15-N3-O7

Major Category

Biological Agents

Synonyms

2-Deoxy-2-(((methylnitrosoamino)carbonyl)amino)-D-glucopyranose; 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; 2-Deoxy-2-(3-methyl-3-nitrosoureido)-alpha(and beta)-D-glucopyranose; D-Glucopyranose, 2-deoxy-2-(((methylnitrosoamino)carbonyl)amino)-; D-Glucose, 2-deoxy-2-(3-methyl-3-nitrosoureido)-; Estreptozocina [INN-Spanish]; N-D-Glucosyl-(2)-N'-nitrosomethylharnstoff [German]; N-D-Glucosyl-(2)-N'-nitrosomethylurea; NRRL 2697; STRZ; STZ; Streptozocine [INN-French]; Streptozocinium [Latin]; Streptozocinum [INN-Latin]; Streptozotocin; U 9889; U-9889; Zanosar; Glucopyranose, 2-deoxy-2-(3-methyl-3-nitrosoureido)-; [ChemIDplus]

Category

Bacterial Toxins

Description

Ivory-colored or pale yellow solid; [HSDB] Light yellow crystalline solid; [MSDSonline]

Sources/Uses

Produced by Streptomyces achromogenas (soil microorganisms); Used to produce diabetes in experimental animals and as an antineoplastic agent; [HSDB]

Comments

Emergency treatment: Symptomatic drug parenteral exposure; [HSDB] Causes diabetes mellitus and increase in liver enzymes in feeding studies of rats with a TDLo =55 mg/kg; [RTECS] Induces diabetes in animals, and diabetes affects pregnancy outcomes; [REPROTOX] May cause irritation; May be harmful by ingestion, inhalation, or skin absorption; Targets pancreas, liver, kidneys, blood, and reproductive system; [Aldrich MSDS]

Exposure Assessment
Vapor Pressure

1.74E-12 mm Hg

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

IARC Carcinogen

Possible Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Other Information

No other related information on this agent was found.