Agent Name

Sulfaquinoxaline

CAS Number

59-40-5

Formula

C14-H12-N4-O2-S

Major Category

Nitrogen Compounds

Synonyms

2-(p-Sulfanilamido)quinoxaline; 2-Sulfanilamidobenzopyrazine; 2-Sulfanilamidoquinoxaline; 2-p-Aminobenzenesulfonamidoquinoxaline; 2-p-Aminobenzenesulphonamidoquinoxaline; 4-Amino-N-2-quinoxalinylbenzenesulfonamide; Anti-K; Avicocid; Compound 3-120; Italquina; Kokozigal; N(sup 1)-(2-Quinoxalinyl)sulfanilamide; N-(2-Quinoxalinyl)sulfanilamide; SQ 40; SQX; Sulfa-Q 20; Sulfabenzpyrazine; Sulfacox; Sulfaline; Sulfaquinoxalina [INN-Spanish]; Sulfaquinoxalinum [INN-Latin]; Sulphaquinoxaline; Sulquin; Ursokoxaline; [ChemIDplus]

Category

Other Aromatics (Nitrogen)

Description

Solid; [Merck Index]

Sources/Uses

Used for treatment of coccidiosis and other bacterial and protozoal infections in animals; Used formerly in the US in combination with warfarin for controlling rats and mice (kills vitamin K-producing bacteria in the digestive tract); [HSDB]

Comments

A flock of chickens treated with 0.05% in feed for 2-3 days, removed 2 days, and treated again for 2-3 days had 47% mortality with hemorrhages, bone marrow pallor, and septicemia; Emergency treatment: "Sulfonamides"; Sulfonamides are used as antibiotics; They can cause hypersensitivity reactions including erythema multiforme and liver injury; Methemoglobinemia and renal failure may occur after toxic ingestions; [HSDB] Causes changes in renal tubules in 26-week, intermittent, oral study of rats (9100 mg/kg); Causes hemorrhage in 14 day intermittent study of dogs (1400 mg/kg); [RTECS] May cause irritation; May cause skin and respiratory sensitization; [Aldrich MSDS]

Restricted

Not registered for use in the US; [HSDB]

Exposure Assessment
Vapor Pressure

3.0E-10 mm Hg

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Processes

Industrial Processes with risk of exposure: