Agent Name

Sulfolane

CAS Number

126-33-0

Formula

C4-H8-O2-S

Major Category

Other Classes

Synonyms

1,1-Dioxidetetrahydrothiofuran; 1,1-Dioxidetetrahydrothiophene; 1,1-Dioxothiolan; 2,3,4,5-Tetrahydrothiophene-1,1-dioxide; Bondelane A; Bondolane A; Cyclic tetramethylene sulfone; Cyclotetramethylene sulfone; Dihydrobutadiene sulfone; Dihydrobutadiene sulphone; Dioxothiolan; Sulfalone; Sulfolan; Sulpholane; Sulphoxaline; Tetrahydrothiofen-1,1-dioxid [Czech]; Tetrahydrothiophene 1,1-dioxide; Tetrahydrothiophene dioxide; Tetramethylene sulfone; Thiacyclopentane dioxide; Thiocyclopentane-1,1-dioxide; Thiolane-1,1-dioxide; Thiophan sulfone; Thiophane dioxide; Thiophene, tetrahydro-, 1,1-dioxide; [ChemIDplus]

Category

Sulfur Compounds

Description

Liquid; mp = 27.4-27.8 deg C; [Merck Index] White solid; [HSDB] Colorless liquid; mp = 26 deg C; [CAMEO] Colorless solid; mp = 27 deg C; [SIDS UNEP] Colorless crystalline solid; mp = 25-28 deg C; [Alfa Aesar MSDS]

Sources/Uses

Used as a solvent (aromatics extraction and polymerization), plasticizer, curing agent (epoxy resins) and therapeutic (antibacterial, convulsant, and radiation-protective agent); Also used for acid gas purification, fractionation (wood tars, tall oil, and other fatty acids), and textile finishing; [HSDB] Used in electronic applications, pharmaceutical manufacturing (solvent), jet printing inks (solvent), and medicines (believed to exist only in patent literature); [SIDS UNEP]

Comments

Not irritating or sensitizing to rabbit skin; Mildly irritating to rabbit eyes; All rats convulsed during aerosolized exposure in lethal-concentration study; Convulsions observed in sub-chronic inhalation studies of dogs and monkeys and clonic-tonic convulsions noted in rats exposed by oral and parenteral routes; Intraperitoneal injection causes decreased metabolic rate and hypothermia in mice and rats; No evidence of mutagenicity; [HSDB] A mild eye irritant; [Alfa Aesar MSDS]

Exposure Assessment
Vapor Pressure

0.0062 mm Hg

Lethal Concentration

LC50 (rat) > 12,000 mg/m3/4h

Explanatory Notes

LC (rat) > 250 mg/m3/8hr; [ChemIDplus]

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Processes

Industrial Processes with risk of exposure: