Agent Name

Tris(1-aziridinyl)phosphine oxide

Alternative Name

Triethylenephosphoramide

CAS Number

545-55-1

Formula

C6-H12-N3-O-P

Major Category

Pesticides

Synonyms

Triethylenephosphoramide; 1,1',1''-Phosphinylidynetrisaziridine; A 6366; APO; Aphoxide; Aziridine, 1,1',1"-phosphinylidynetris-; CBC 906288; Imperon fixer T; N,N',N"-Triethylenephosphoramide; N,N',N''-Tri-1,2-ethanediylphosphoric triamide; N,N',N''-Triethylenephosphoric triamide; Phosphine oxide, tris(1-aziridinyl)-; Phosphoramide, N,N',N -triethylene-; Phosphoramide, N,N',N"-triethylene-; Phosphoric acid triethylene imide; Phosphoric triamide, N,N',N -triethylene-; Phosphoric triamide, N,N',N"-triethylene-; Phosphoric triamide, N,N',N''-tri-1,2-ethanediyl-; SK-3818; TAPO; TEF; TEPA; TEPA (VAN); Tri-1-aziridinylphosphine oxide; Triaethylenphosphorsaeureamid [German]; Triaziridinophosphine oxide; Triaziridinylphosphine oxide; Triethylene phophoramide; Triethylene phosphoramide; Triethylenephosphoric triamide; Triethylenephosphorotriamide; Triethylenepyrophosphoramide; Triethylenfosforamid [Czech]; Tris(1-aziridine)phosphine oxide; Tris(N-ethylene)phosphorotriamidate; Tris(aziridinyl)phosphine oxide; Tris-(1-aziridinyl)-phosphineoxide; Tris-(1-aziridinyl)fosfinoxid [Czech]; [ChemIDplus] UN2501

Category

Insect Sterilants

Description

Colorless solid; [Hawley]

Sources/Uses

Used as an antineoplastic medication, insect sterilant, and to flame-proof cotton; [Hawley] Used as a pesticide for mites and ticks, a photographic emulsion hardener, and an agent in permanent-press treatment of cotton, textile dyeing, and polymer stabilizing; [HSDB]

Comments

No longer used or produced commercially in the US; [HSDB] Known human carcinogen; [Merck Index] Prolonged contact can burn skin and eyes; Repeated exposure may lead to sensitization; Toxic by ingestion, inhalation, or skin absorption; [CAMEO] See "Thiotepa."

Exposure Assessment
Vapor Pressure

0.0063 mm Hg

Explanatory Notes

The Guide from the Emergency Response Guidebook is for "Tris(1-aziridinyl)phosphine oxide, solution."

Adverse Effects
Dermatotoxin

Skin Burns

IARC Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Processes

Industrial Processes with risk of exposure: