Agent Name

Terephthalic acid

Alternative Name

p-Phthalic acid

CAS Number

100-21-0

Formula

C8-H6-O4

Major Category

Other Classes

Synonyms

1,4-Benzenedicarboxylic acid; Acide terephtalique [French]; Kyselina tereftalova [Czech]; TA 12; TA-33MP; Tephthol; WR 16262; p-Benzenedicarboxylic acid; p-Carboxybenzoic acid; p-Dicarboxybenzene; p-Phthalic acid; para-Phthalic acid; [ChemIDplus]

Category

Organic Acids

Description

White solid; [Hawley] Odorless or a slight acetic acid odor; [CHEMINFO] Off-white powder; [MSDSonline]

Sources/Uses

Used in wool processing and making plastic films and sheets; Also added to poultry feeds and to certain antibiotics to increase their effectiveness; [HSDB]

Comments

Practically nontoxic in acute, high-dose animal studies; In high-dose feeding studies in rats, it causes bladder stones and subsequent bladder cancers; The bladder cancers are thought to be secondary to the presence of bladder stones. [ACGIH] A skin and eye irritant; [ICSC] An irritant; Effects in high-dose animal studies include abnormal liver function tests; [MSDSonline]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

10 mg/m3

MAK

5 mg/m3, inhalable fraction

Vapor Pressure

9.2E-6 mm Hg

Explanatory Notes

Flash point = 260 deg C; [ICSC]

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Processes

Industrial Processes with risk of exposure: