Agent Name

Tetrakis(hydroxymethyl)phosphonium sulfate

CAS Number

55566-30-8

Formula

C8-H24-O8-P2.O4-S

Major Category

Other Classes

Synonyms

Bis(tetrakis(hydroxymethyl)phosphonium)sulfate (salt); Octakis(hydroxymethyl)phosphonium sulfate; Phosphonium, tetrakis(hydroxymethyl)-, sulfate (2:1) (salt); Pyroset TKO; THPS; Retardol S; [ChemIDplus]

Category

Phosphorus Compounds

Description

Crystalline solid; [ACGIH] Available commercially as an aqueous solution; [MSDSonline]

Sources/Uses

Used to make crease-resistant and flame-retardant finishes for textiles, e.g., children's sleepwear; [ACGIH] Also used as a biocide; [HSDB]

Comments

May cause sensitization by skin contact or inhalation; [CHEMINFO] Tetrakis (hydroxymethyl) phosphonium sulfate (THPS) was a sensitizer in 14 of 20 guinea pigs; Fabric impregnated with THPC or THPS does not cause skin sensitization. THPS did not inhibit acetylcholinesterase in vitro; Rats and mice given repeated high oral doses have liver damage; Degrades rapidly in the environment in the presence of moisture and sunlight into trihydroxymethyl phosphine oxide and bis-hydroxymethyl phosphonic acid; [ACGIH] Harmful if swallowed; Corrosive; Causes burns; May cause skin sensitization; Inhalation of high concentrations may cause pneumonitis and pulmonary edema; [Sigma-Aldrich MSDS] See "Tetrakis(hydroxymethyl)phosphonium chloride."

Exposure Assessment
Skin Designation (ACGIH)

No

TLV (ACGIH)

2 mg/m3

Lethal Concentration

LC50 (Rat) = 5.5 mg/l/4 hr

Explanatory Notes

VP = 32 mm Hg @ 124 deg F; [CAMEO] Tetrakis(hydroxymethyl)phosphonium sulfate and Tetrakis(hydroxymethyl)phosphonium chloride are addressed by ACGIH in a single profile for Tetrakis(hydroxymethyl)phosphonium salts. See ACGIH Documentation of TLVs.

Adverse Effects
Skin Sensitizer

Yes

Toxic Pneumonitis

Yes

Hepatotoxin

Hepatotoxin, Secondary

Dermatotoxin

Skin Burns

IARC Carcinogen

Not Classifiable

ACGIH Carcinogen

Not Classifiable

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Chemical Information

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