Agent Name

Tetramethylurea

CAS Number

632-22-4

Formula

C5-H12-N2-O

Major Category

Nitrogen Compounds

Synonyms

1,1,3,3-Tetramethylurea; N,N,N',N'-Tetramethylurea; TMU; Temur; Tetramethyluree [French]; Urea, 1,1,3,3-tetramethyl-; Urea, tetramethyl-; Urea, N,N,N',N'-tetramethyl-; [ChemIDplus]

Category

Urea Compounds

Description

Liquid with mild pleasant odor; [Merck Index] Colorless liquid; [Alfa Aesar MSDS]

Sources/Uses

Used as solvent and reagent; [Merck Index]

Comments

Teratogenic effects observed in mice dosed by SC injection; IV doses of 150 mg/kg daily for five days produced weight loss in dogs, monkeys, and mice; [HSDB] A strong skin irritant, but not a sensitizer in guinea pigs; Temporary kidney injury and possible liver injury observed in two week feeding study of male rats at 450 mg/kg; [ToxPlanet: EPA] Causes general anesthesia and somnolence in IP lethal-dose study of mice; [RTECS] Teratogenic effects and fetal loss observed in studies of rodents; No human data on reproductive or lactation effects; [REPROTOX] An irritant; [Alfa Aesar MSDS]

Exposure Assessment
Lethal Concentration

LCLo (rat) = 312 ppm/4h

Explanatory Notes

VP = 13.9 mm Hg at 71 deg C; [ChemIDplus]

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Other Information

No other related information on this agent was found.