Agent Name

Tetrodotoxin

CAS Number

4368-28-9

Formula

C11-H17-N3-O8

Major Category

Biological Agents

Synonyms

(4R-(4alpha,4aalpha,5alpha,7alpha,9alpha,10alpha,10abeta,11S*,12S*))-Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-(1,3)dioxocino(6,5-d) pyrimidine-4,7,10,11,12-pentol; 5,9:7,10a-Dimethano-10aH-(1,3)dioxocino(6,5-d)pyrimidine-4,7,10,11,12-pentol, octahydro-12-(hydroxymethyl)-2-imino-, (4R-(4alpha,4aalpha,5alpha,7alpha,9alpha,10alpha,10abeta,11S*,12S*))-; BJT 1; Babylonia japonica toxin 1; Fugu poison; Maculotoxin; Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-(1,3)dioxocino(6,5-d)pyrimidine-4,7,10,11,12-pentol; Spheroidine; TTX; Tarichatoxin; Tetrodontoxin; Tetrodotoxine; Tetrodoxin; [ChemIDplus] UN3462

Category

Seafood Toxins

Description

Solid; [HSDB] Colorless solid; [NIOSH] White powder; [MSDSonline]

Sources/Uses

Toxin from the ovaries and liver of Tetraodontidae species (especially the globe fish); [Merck Index] Used for physiological studies; [HSDB] Very potent toxin from the liver and sex organs of fish (i.e., puffer fish, globe fish, and toadfish); Also found in some amphibians, octopus, and shellfish; [Reference #1]

Comments

Poisonings result from ingestion; Interferes with nerve to muscle signal transmission (blocks sodium channels) causing rapid muscle weakness and paralysis; May cause respiratory paralysis and death; [Reference #1] Onset of action after ingestion is 30-40 minutes. Symptoms include vomiting, paresthesias, muscle twitching, weakness, and respiratory paralysis. [Olson, p. 220] May cause irritation; May be fatal by ingestion, inhalation, or skin absorption; Targets nerves and skeletal muscles; [MSDSonline]

Reference Link

The Emergency Response Safety and Health Database: Biotoxin: TETRODOTOXIN

Exposure Assessment
Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Toxins, extracted from living sources, solid, n.o.s."

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Other Information

No other related information on this agent was found.