Agent Name

Thiophanate-methyl

CAS Number

23564-05-8

Formula

C12-H14-N4-O4-S2

Major Category

Pesticides

Synonyms

1,2-Bis(3-(methoxycarbonyl)-2-thioureido)benzene; 1,2-Bis(methoxycarbonylthioureido)benzene; 1,2-Di-(3-methoxycarbonyl-2-thioureido)benzene; BAS 32500F; Caligran; Cercobin M; Cercobin methyl; Cycosin; Dimethyl ((1,2-phenylene)bis-(iminocarbonothioyl))bis(carbamate); Dimethyl 4,4'-o-phenylenebis(3-thioallophanate); Ditek; Easout; Enovit M; Enovit Super; Enovit methyl; F 6385; Fungo; Fungo 50; Methyl thiophanate; Methyl topsin; Methylthiofanate; Methylthiophanate; Metoben; Mildothane; NF 44; Neotopsin; PEI 190; PELT 14; PELT-44; Rilon; Sipcaplant; Sipcasan; Sipcavit; TD 1771; Thiopan; Thiophanate M; Thiophanate methyl; Tiofanate metile [Italian]; Topsin M; Topsin Methyl; Topsin NF 44; Topsin NF-44; Topsin WP methyl; Topsin turf and ornamentals; Topsin-M; Trevin; o-Bis(3-methoxycarbonyl-2-thioureido)benzene; Allophanic acid, 4,4'-o-phenylenebis(3-thio-, dimethyl ester; Carbamic acid, (1,2-phenylenebis(iminocarbonothioyl))bis-, dimethyl ester; [ChemIDplus]

Category

Fungicides

Description

Colorless solid; [Merck Index] Colorless or light brown solid; [CAMEO] Colorless crystalline solid; [MSDSonline]

Sources/Uses

Used as fungicide to control disease (vegetables, fruits, turf, and other crops) and protect wounds (fruit trees); [HSDB] Used as veterinary anthelmintic (nematodes); [Merck Index]

Comments

Mildly irritating to skin and eyes; Does not inhibit the cholinesterase enzyme; Effects in high-dose animal studies include convulsions; In chronic feeding studies of mice, thyroxin (T4) levels were low, and TSH levels were high; Causes developmental and reproductive effects at maternotoxic doses; [HSDB] May cause irritation; [CAMEO] May cause skin sensitization; [eChemPortal: ESIS] A skin sensitizer in animal testing; [Reference #1]

Reference Link

EPA Pesticide Chemical Search

Exposure Assessment
Vapor Pressure

7.13E-8 mm Hg

Lethal Concentration

LC50 (rat) = 1,700 mg/m3/4h

Adverse Effects
Skin Sensitizer

Yes

Neurotoxin

Other CNS Neurotoxin

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: