Agent Name

Diaminotoluene, mixed isomers

Alternative Name

Toluenediamine, mixed isomers

CAS Number

25376-45-8

Formula

C7-H10-N2

Major Category

Nitrogen Compounds

Synonyms

Toluenediamine, mixed isomers; Toluene-ar,ar'-diamine; Methylphenylenediamine; Phenylenediamine, ar-methyl-; TDA 8020; Toluenediamine; Tolylenediamine; Benzenediamine, ar-methyl-; [ChemIDplus] UN1709

Category

Amines, Aromatic

Description

White, yellow, or tan solid with an ammonia-like odor; Darkens upon exposure to light and air or upon extended storage, turning deep violet or black; [CHEMINFO] Light yellow solid; [MSDSonline]

Sources/Uses

Used as a chemical intermediate in the preparation of fungicides; [HSDB] There are 6 isomers of TDA, but only 2,4-, 2,5-, and 2,6-TDA are of commercial interest; Used to make toluene diisocyanate; [AIHA]

Comments

A skin sensitizer; May cause lacrimation and chemosis in the eyes; [HSDB] No skin sensitization was detected in a study of 31 human volunteers; May stain skin yellow; [AIHA] May cause irritation; May induce methemoglobinemia; Can be absorbed through skin; Acute overexposure may cause liver and kidney injury and anemia; [MSDSonline] See "2,4-Diaminotoluene" and "2,5-Diaminotoluene."

Exposure Assessment
WEEL

0.005 ppm

Vapor Pressure

0.0014 mm Hg

Explanatory Notes

Flash Point = 140 deg C; [CHEMINFO] The Guide in the Emergency Response Guidebook is for "2,4-Toluenediamine."

Adverse Effects
Skin Sensitizer

Yes

Lacrimator

Yes

Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: