Agent Name

T-2 toxin

CAS Number

21259-20-1

Formula

C24-H34-O9

Major Category

Biological Agents

Synonyms

12,13-Epoxytrichothec-9-ene-3,4,8,15-tetrol 4,15-diacetate 8-(3-methylbutanoate); 12,13-Epoxytrichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol 4,15-diacetate 8-isovalerate; 12,13-Epoxytrichothec-9-ene-3alpha,4beta,8alpha,15-tetrol, 4,15-diacetate 8-isovalerate; 3-Hydroxy-4,15-diacetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-delta(sup 9)-trichothecene; 3-Hydroxy-4,15-diacetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-delta-9-trichothecene; 3alpha-Hydroxy-4beta-15-diacetoxy-8alpha-(3-methylbutyryloxy)-12,13-epoxy-delta9-tricothecene; 4,15-Diacetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-delta-9-trichothecen-3-ol; 4,15-Diacetoxy-8-(3-methylbutyryloxy)scirp-9-en-3-ol; 4-beta,15-Diacetoxy-8-alpha-(3-methylbutyryloxy)-3-alpha-hydroxy-12,13-epoxytrichothec-9-ene; 8-(3-Methylbutyryloxy)-diacetoxyscirpenol; 8alpha-(3-Methylbutyryloxy)-4beta,15-diacetoxyscirp-9-en-3alpha-ol; Fusariotoxin T 2; Fusariotoxine T2; Insariotoxin; Isaritoxin; Mycotoxin T-2; Scirpenol, 8-(3-methylbutyryloxy)-diacetoxy-; T(sub 2)-Trichothecene; T-2 mycotoxin; T-2 Toxin; T2-Trichothecene; Toxin T2; Trichothec-9-ene-3,4,8,15-tetrol, 12,13-epoxy-, 4,15-diacetate 8-(3-methylbutanoate), (3alpha,4beta,8alpha)-; Trichothec-9-ene-3alpha,4beta,8alpha,15-tetrol, 12,13-epoxy-, 4,15-diacetate 8-isovalerate; [ChemIDplus] UN3462

Category

Mycotoxins

Description

White solid; [HSDB] White powder; [MSDSonline]

Sources/Uses

Trichothecene mycotoxin found in Fusarium tricinctum; Thought to be used in the past as a chemical warfare agent in Southeast Asia; [Merck Index] Produced by various Fusarium fungi; Human exposure has occurred from consumption of contaminated cereals; [HSDB] Produced mainly by Fusarium sporotrichioides; Occasionally found on cereals like wheat and maize; Caused mass human poisonings in Siberia in the last century; [IARC]

Comments

May cause severe irritation and tissue necrosis to skin and mucous membranes; Topical application has caused systemic toxicicity and death in animal studies; [Merck Index] A strong skin irritant; May cause blistering and necrosis to skin; Trichothecene mycotoxins causes bone marrow suppression, leukopenia, immunosuppression, and secondary sepsis; [HSDB] Within minutes, the effects of T-2 mycotoxin include irritation of the skin and injury to the GI and respiratory tracts. In severe cases patients have skin necrosis, fever, ataxia, epistaxis, chest pain, wheezing, hemoptysis, bone marrow depression, hemorrhagic diathesis, and shock. [Weinstein, p. 104]

Exposure Assessment
Lethal Concentration

LC50 (rat) = 20 mg/m3/10min

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Toxins, extracted from living sources, solid, n.o.s."

Adverse Effects
Toxic Pneumonitis

Yes

Dermatotoxin

Skin Burns

IARC Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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