Agent Name

trans-Diamminedichloroplatinum

Alternative Name

Transplatin

CAS Number

14913-33-8

Formula

Cl2-H6-N2-Pt

Major Category

Metals

Synonyms

Transplatin; trans-DDP; trans-Diamminedichloroplatinum (II); trans-Diamminedichloroplatinum(II); trans-Dichlorodiammine platinum; trans-Dichlorodiammineplatinum (II); trans-Dichlorodiammineplatinum(II); trans-Platinum(II) ammonium chloride; trans-Platinum(II) diamminedichloride; trans-Platinum(II)diamminedichloride; trans-Platinumdiammine dichloride; Diamminedichloroplatinum (trans); Platinum (II), diamminedichloro-, trans-; Platinum, diamminedichloro-, (SP-4-1)-; Platinum, diamminedichloro-, trans- (8CI); [ChemIDplus]

Category

Metals, Inorganic Compounds

Description

Yellow crystalline solid; [MSDSonline]

Sources/Uses

Used in plating baths; [HSDB]

Comments

The allergenic compounds appear to be limited to the "coordination complexes containing halogen ligands as leaving groups . . . Neutral coordination complexes such as diamminedichloroplatinum do not seem to be allergenic." [Nordberg, p. 1125] Cisplatin, used as a cancer drug, is toxic to the kidneys as high doses; A potential skin and respiratory sensitizer; In high-dose animal experiments by subcutaneous route, causes seizures, coma, and death; Oral LD50 (rat) >5110 mg/kg; [HSDB] An irritant; May cause skin and respiratory sensitization after prolonged contact; [MSDSonline]

Exposure Assessment
TLV (ACGIH)

0.002 mg/m3, as Pt

PEL (OSHA)

0.002 mg/m3, as Pt

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Processes

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