Agent Name

Vinyl toluene

Alternative Name

Methyl styrene

CAS Number




Major Category

Plastics & Rubber


Methyl styrene; 3- and 4-Vinyl toluene (mixed isomers); Benzene, ethenylmethyl-; Ethenylmethylbenzene; Methylethenylbenzene; Methylstyrene; Methylvinylbenzene; Styrene, ar-methyl-; Styrene, methyl- (mixed isomers); Toluene, vinyl- (mixed isomers); Tolylethylene; Vinyl toluene; Vinyltoluene; Vinyltoluene,industrial; alpha,beta-Styrene; [ChemIDplus] UN2618




Colorless liquid with a strong, disagreeable odor; [NIOSH]


Used as a monomer in the production of plastics and surface coatings and as an intermediate in the synthesis of certain insecticides; [ACGIH]


Vinyl toluene is similar to styrene in its toxicological properties. Fatty degeneration of the liver occurs in acute animal studies. Human subjects found the odor detectable at 50 ppm and objectionable at 300 ppm. [ACGIH] Mainly an eye and respiratory tract irritant, it can cause central nervous system depression after absorption of high doses. [NIOSH Guidelines for Chemical Hazards] A skin, eye, and respiratory tract irritant; Inhalation of high concentrations may cause CNS effects; May cause liver injury; [ICSC] Vinyltoluenes, stabilized (UN2618) has warning of explosive polymerization; [ERG 2016]

Exposure Assessment
Skin Designation (ACGIH)



50 ppm


100 ppm


100 ppm


100 ppm


400 ppm

Excerpts from Documentation for IDLHs

Other animal data: A considerable number of rats and guinea pigs exposed to 3,000 ppm for 7 to 8 hours/day, 5 days/week for up to 6 months died [Gerarde 1960; Wolf et al. 1956]. Rats and guinea pigs had slight changes in liver and kidney weights and some reduction in body weight following exposure to 800 ppm for 7 hours/day, 5 days/week for 27 days [Wolf et al. 1956]. No adverse effects were noted in rats, rabbits, mice, monkeys, and guinea pigs exposed 7 hours/day, 5 days/week for 5 months to 200 ppm [Wolf et al. 1956]. . . . Human data: Four volunteers reported a definite unpleasant odor and slight eye irritation after about 2 minutes of exposure to 200 ppm [Wolf et al. 1956]. Strong eye and nasal irritation has been noted at concentrations above 600 ppm [Gerarde 1960; Wolf et al. 1956].

Vapor Pressure

1 mm Hg

Odor Threshold Low

10 ppm

Lethal Concentration

LC50 (mice) = 3,020 mg/m3/4h

Explanatory Notes

Odor threshold from "Quick Guide: The Electronic NIOSH Pocket Guide to Chemical Hazards"; Flash point = 60 deg C;

Adverse Effects

CNS Solvent Syndrome


Hepatotoxin, Secondary

IARC Carcinogen

Not Classifiable

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information


Chemical Information

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Related Information in HazMap

Occupational diseases associated with exposure to this agent:


Industrial Processes with risk of exposure: