Agent Name

Triethylene glycol monobutyl ether

Alternative Name

TEGBE

CAS Number

143-22-6

Formula

C10-H22-O4

Major Category

Solvents

Synonyms

2-(2-(2-Butoxyethoxy)ethoxy)ethanol; 3,6,9-Trioxa-1-tridecanol; Butoxytriethylene glycol; Butoxytriglycol; Dowanol TBAT; Poly-Solv TB; Triethylene glycol butyl ether; Triethylene glycol mono-n-butyl ether; Triethylene glycol n-butyl ether; Triglycol monobutyl ether; Ethanol, 2-(2-(2-butoxyethoxy)ethoxy)-; [ChemIDplus] TGBE; [eChemPortal: SIDSUNEP]

Category

Glycol Ethers (E Series)

Description

Colorless liquid; [ICSC] Colorless to yellow hygroscopic liquid; [CHEMINFO] Faintly yellow-green liquid; [MSDSonline]

Sources/Uses

Used as plasticizer, intermediate, and solvent (resins, paints, metal cleansing agents, pharmaceuticals, cosmetics, greases, and oils) ; Also used in wood preservatives, cutting and hydraulic oils, inks, and in the leather, textile, and transportation industries; [HSDB] Used mainly in automotive hydraulic brake fluids; Also used as a solvent and intermediate; [eChemPortal: SIDSUNEP]

Comments

High-dose animal studies: Not genotoxic; Doses >1000 mg/kg/day cause liver injury; Repeated oral doses >4000 mg/kg/day cause testicular injury; Not a developmental toxin at doses <1000 mg/kg/day; No deaths after inhalation of saturated solution for 8 hours; [Reference #1] An eye and mild skin irritant; [ICSC] In lethal-dose animal studies after oral administration, causes flaccid paralysis; [RTECS] A strong eye irritant, based on animal studies; [HSDB] A mild to moderate skin irritant; Very irritating to eyes; [eChemPortal: SIDSUNEP] May cause serious eye injury; [eChemPortal: ESIS] See "GLYCOL ETHERS."

Reference Link

OECD SIDS: High Boiling Ethylene Glycol Ethers - 2002

Exposure Assessment
Vapor Pressure

0.0025 mm Hg

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: