Agent Name

Triethylene glycol monomethyl ether

Alternative Name

TEGME

CAS Number

112-35-6

Formula

C7-H16-O4

Major Category

Solvents

Synonyms

2-(2-(2-Methoxyethoxy)ethoxy)ethanol; 3,6,9-Trioxa-1-decanol; Dowanol TMAT; Ethanol, 2-(2-(2-methoxyethoxy)ethoxy)-; Methoxytriethylene glycol; Methoxytriglycol; Methyl triethylene glycol; Methyltrioxitol; Poly-Solv TM; Triethylene glycol methyl ether; Triethylene glycolmonomethyl ether; Triglycol monomethyl ether; [ChemIDplus] TGME; [eChemPortal: SIDSUNEP]

Category

Glycol Ethers (E Series)

Description

Colorless liquid; [HSDB] Odorless; [CAMEO]

Sources/Uses

Used as coupling solvent (water-based paints), for blending brake and hydraulic fluids, and as a plasticizer and wetting agent (resins and paints); [HSDB] Used as raw material for automotive hydraulic brake fluids and a solvent in coatings, printing inks, cleaning products, cutting oils, and deicing agents; [eChemPortal: SIDSUNEP]

Comments

In lethal-dose animal studies, causes liver injury; Oral doses of 4000 mg/kg/day for 91 days cause testicular injury in rats; Developmental toxicity is seen in rats receiving >1000 mg/kg/day; Genotoxic studies were negative; [Reference # 1] No listed effects of short-term or long-term exposure; [ICSC] May form unstable peroxides in the presence of oxygen; [CAMEO] May cause mild skin and eye irritation; [eChemPortal: SIDSUNEP] See "GLYCOL ETHERS."

Reference Link

OECD SIDS: 2-(2-(2-Methoxyethoxy)ethoxy)ethanol - 1996

Exposure Assessment
MAK

50 mg/m3. inhalable fraction

Vapor Pressure

0.0035 mm Hg

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: