Agent Name

Triethylene glycol monomethyl ether

Alternative Name

TEGME

CAS Number

112-35-6

Formula

C7-H16-O4

Major Category

Solvents

Synonyms

2-(2-(2-Methoxyethoxy)ethoxy)ethanol; 3,6,9-Trioxa-1-decanol; Dowanol TMAT; Ethanol, 2-(2-(2-methoxyethoxy)ethoxy)-; Methoxytriethylene glycol; Methoxytriglycol; Methyl triethylene glycol; Methyltrioxitol; Poly-Solv TM; Triethylene glycol methyl ether; Triethylene glycolmonomethyl ether; Triglycol monomethyl ether; [ChemIDplus] TGME; [eChemPortal: SIDSUNEP]

Category

Glycol Ethers (E Series)

Description

Colorless liquid; [HSDB] Odorless; [CAMEO]

Sources/Uses

Used as coupling solvent (water-based paints), for blending brake and hydraulic fluids, and as a plasticizer and wetting agent (resins and paints); [HSDB] Used as raw material for automotive hydraulic brake fluids and a solvent in coatings, printing inks, cleaning products, cutting oils, and deicing agents; [eChemPortal: SIDSUNEP]

Comments

In lethal-dose animal studies, causes liver injury; Oral doses of 4000 mg/kg/day for 91 days cause testicular injury in rats; Developmental toxicity is seen in rats receiving >1000 mg/kg/day; Genotoxic studies were negative; [Reference # 1] No listed effects of short-term or long-term exposure; [ICSC] May form unstable peroxides in the presence of oxygen; [CAMEO] May cause mild skin and eye irritation; [eChemPortal: SIDSUNEP] See "GLYCOL ETHERS."

Reference Link

OECD SIDS: 2-(2-(2-Methoxyethoxy)ethoxy)ethanol - 1996

Exposure Assessment
MAK

50 mg/m3. inhalable fraction

Vapor Pressure

0.0035 mm Hg

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: