Agent Name

p-Anisidine

CAS Number

104-94-9

Formula

C7-H9-N-O

Major Category

Nitrogen Compounds

Synonyms

1-Amino-4-methoxybenzene; 4-Aminoanisole; 4-Anisidine; 4-Methoxy-1-aminobenzene; 4-Methoxyaniline; 4-Methoxybenzenamine; 4-Methoxybenzeneamine; Aniline, 4-methoxy-; Aniline, p-methoxy-; Anisole, p-amino-; Benzenamine, 4-methoxy-; p-Aminoanisole; p-Anisylamine; p-Dianisidine; p-Methoxyaniline; p-Methoxyphenylamine; [ChemIDplus] UN2431

Category

Amines, Aromatic

Description

Yellow to brown, crystalline solid with an amine-like odor; [NIOSH]

Sources/Uses

Both ortho and para isomers are used to produce azo dyes, while only the ortho form is used to produce synthetic guaiacol; [ACGIH]

Comments

Bladder cancer in animals observed in chronic feeding studies; Methemoglobinemia has been reported in exposed workers. Listed in the table "Examples of Industrial Chemicals for Which Methemoglobin Formation is NOT the Principal Cause of Toxicity"; [ACGIH] IARC classifies p-Anisidine as 3 (Not classifiable as to carcinogenicity to humans) and o-Anisidine as 2B (possibly carcinogenic to humans). A skin, eye, and respiratory tract irritant; Can induce methemoglobinemia; [ICSC]

Exposure Assessment
BEI

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Skin Designation (ACGIH)

Yes

TLV (ACGIH)

0.5 mg/m3

PEL (OSHA)

0.5 mg/m3

IDLH (NIOSH)

50 mg/m3

Excerpts from Documentation for IDLHs

Other animal data: Mice have survived exposures to concentrations of 10 to 30 mg/m3 for 2 hours/day, 6 days/week for 1 month with a only decrease in the excitability of nerves noted [Zaeva and Fedorova 1962]. Human data: None relevant for use in determining the revised IDLH.

Vapor Pressure

0.03 mm Hg

Explanatory Notes

Flash point = 5 deg C; [HSDB]

Adverse Effects
Methemoglobinemia

Methemoglobinemia, Secondary

IARC Carcinogen

Not Classifiable

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Other Information

No other related information on this agent was found.