Agent Name

m-(Trifluoromethyl)aniline

CAS Number

98-16-8

Formula

C7-H6-F3-N

Major Category

Nitrogen Compounds

Synonyms

1-Amino-3-(trifluoromethyl)benzene; 3-(Trifluoromethyl)aniline; 3-(Trifluoromethyl)benzenamine; 3-Aminobenzotrifluoride; 3-Trifluoromethyl aniline; Benzenamine, 3-(trifluoromethyl)-; Toluene, 3-amino-alpha,alpha,alpha-trifluoro-; alpha,alpha,alpha-Trifluoro-m-toluidine; m-ABTF; m-Amino-alpha,alpha,alpha-trifluorotoluene; m-Aminobenzal fluoride; m-Aminobenzotrifluoride; m-Toluidine, alpha,alpha,alpha-trifluoro-; 3-Trifluoromethylaniline; [ChemIDplus] UN2948

Category

Amines, Aromatic

Description

mp = 5.5 deg C; [ChemIDplus] Colorless to yellow liquid with a fishy odor; [HSDB] Colorless liquid; [MSDSonline]

Sources/Uses

Used as intermediate for phenothiazine derivatives, herbicides, antihypertensives, and diuretics; [HSDB] Used to make dyes; [CAMEO]

Comments

A moderate eye irritant; In lethal-dose feeding studies, causes methemoglobinemia, somnolence, and fatty liver degeneration; [RTECS] A corrosive chemical that could cause chemical pneumonitis after inhalation; Methemoglobinemia reported in animal experiments; Monitor liver and kidney function after significant exposure; [HSDB] May burn skin and eyes; [CAMEO] An irritant; Can be absorbed through skin; [MSDSonline]

Exposure Assessment
Vapor Pressure

0.59 mm Hg

Lethal Concentration

LC50 (rat) = 440 mg/m3/4h

Adverse Effects
Toxic Pneumonitis

Yes

Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Related Information in HazMap
Other Information

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