Agent Name

1-Chloro-4-(trifluoromethyl)benzene

Alternative Name

p-Chlorobenzotrifluoride

CAS Number

98-56-6

Formula

C7-H4-Cl-F3

Major Category

Other Classes

Synonyms

p-Chlorobenzotrifluoride; (p-Chlorophenyl)trifluoromethane; 1-(Trifluoromethyl)-4-chlorobenzene; 4-Chloro-alpha,alpha,alpha-trifluorotoluene; 4-Chlorobenzotrifluoride; Benzene, 1-chloro-4-(trifluoromethyl)-; Toluene, p-chloro-alpha,alpha,alpha-trifluoro-; alpha,alpha,alpha-Trifluoro-4-chlorotoluene; p-(Trifluoromethyl)chlorobenzene; p-Chloro-alpha,alpha,alpha-trifluorotoluene; p-Chlorotrifluoromethylbenzene; p-Trifluoromethylphenyl chloride; para-Chloro-alpha,alpha,alpha-trifluorotoluene; para-Chlorobenzotrifluoride; para-Chlorotrifluoromethylbenzene; [ChemIDplus] UN2234

Category

Halogenated Monoaromatics

Description

Liquid with a strong but not unpleasant odor; [Merck Index] Clear colorless liquid; [CAMEO]

Sources/Uses

Used as an intermediate for dyes and pesticides; Also used as a environmentally friendly solvent and dielectric fluid; [Merck Index]

Comments

A skin, eye, mucous membrane, and respiratory tract irritant; Inhalation of high concentrations can cause CNS depression; [CAMEO] A skin and eye irritant; In a two generation reproductive feeding study with rats, the NOAEL in F1 and F2 offspring was greater than or equal to the highest dose tested (45 mg/kg bw); No evidence of mutagenicity; [IUCLID] Effects observed from single oral dose in rats include ataxia, tremors, and decreased limb tone; Effects observed in F1 female rats in oral reproductive study include increase in SGPT, decrease in erythrocyte counts, and lesions in the lungs; Decrease in erythrocytes, hemoglobin, and mean corpuscular and packed cell volumes observed in male rats in 90 day oral study; Increased liver weights observed in both sexes; No evidence of mutagenicity; [EPA] Effects observed in feeding studies at 400 mg/kg include liver hypertrophy in rats and mice and adrenal changes in rats; Doses of 50 mg/kg caused nephropathy in male rats; [NTP]

Exposure Assessment
Vapor Pressure

7.63 mm Hg

Lethal Concentration

LC50 (rat) = 22,000 mg/m3

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Chlorobenzotrifluorides."

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: