Agent Name

1-Chloro-4-(trifluoromethyl)benzene

Alternative Name

p-Chlorobenzotrifluoride

CAS Number

98-56-6

Formula

C7-H4-Cl-F3

Major Category

Other Classes

Synonyms

p-Chlorobenzotrifluoride; (p-Chlorophenyl)trifluoromethane; 1-(Trifluoromethyl)-4-chlorobenzene; 4-Chloro-alpha,alpha,alpha-trifluorotoluene; 4-Chlorobenzotrifluoride; Benzene, 1-chloro-4-(trifluoromethyl)-; Toluene, p-chloro-alpha,alpha,alpha-trifluoro-; alpha,alpha,alpha-Trifluoro-4-chlorotoluene; p-(Trifluoromethyl)chlorobenzene; p-Chloro-alpha,alpha,alpha-trifluorotoluene; p-Chlorotrifluoromethylbenzene; p-Trifluoromethylphenyl chloride; para-Chloro-alpha,alpha,alpha-trifluorotoluene; para-Chlorobenzotrifluoride; para-Chlorotrifluoromethylbenzene; [ChemIDplus] UN2234

Category

Halogenated Monoaromatics

Description

Liquid with a strong but not unpleasant odor; [Merck Index] Clear colorless liquid; [CAMEO]

Sources/Uses

Used as an intermediate for dyes and pesticides; Also used as a environmentally friendly solvent and dielectric fluid; [Merck Index]

Comments

A skin, eye, mucous membrane, and respiratory tract irritant; Inhalation of high concentrations can cause CNS depression; [CAMEO] A skin and eye irritant; In a two generation reproductive feeding study with rats, the NOAEL in F1 and F2 offspring was greater than or equal to the highest dose tested (45 mg/kg bw); No evidence of mutagenicity; [IUCLID] Effects observed from single oral dose in rats include ataxia, tremors, and decreased limb tone; Effects observed in F1 female rats in oral reproductive study include increase in SGPT, decrease in erythrocyte counts, and lesions in the lungs; Decrease in erythrocytes, hemoglobin, and mean corpuscular and packed cell volumes observed in male rats in 90 day oral study; Increased liver weights observed in both sexes; No evidence of mutagenicity; [EPA] Effects observed in feeding studies at 400 mg/kg include liver hypertrophy in rats and mice and adrenal changes in rats; Doses of 50 mg/kg caused nephropathy in male rats; [NTP]

Exposure Assessment
Vapor Pressure

7.63 mm Hg

Lethal Concentration

LC50 (rat) = 22,000 mg/m3

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Chlorobenzotrifluorides."

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: