Agent Name

p-Nitrochlorobenzene

Alternative Name

p-Chloronitrobenzene

CAS Number

100-00-5

Formula

C6-H4-Cl-N-O2

Major Category

Nitrogen Compounds

Synonyms

p-Chloronitrobenzene; 1-Chloor-4-nitrobenzeen [Dutch]; 1-Chlor-4-nitrobenzol [German]; 1-Chloro-4-nitrobenzene; 1-Cloro-4-nitrobenzene [Italian]; 1-Nitro-4-chlorobenzene; 4-Chloro-1-nitrobenzene; 4-Chloronitrobenzene; 4-Nitro-1-chlorobenzene; 4-Nitrochlorobenzene; Benzene, 1-chloro-4-nitro-; PNCB; p-Chloronitrobenzene; p-Nitrochloorbenzeen [Dutch]; p-Nitrochlorobenzene; p-Nitrochlorobenzol [German]; p-Nitroclorobenzene [Italian]; p-Nitrophenyl chloride; [ChemIDplus] UN1578

Category

Nitros, Aromatic

Description

Light yellow crystalline solid with a sweet odor; [CAMEO]

Sources/Uses

Used to manufacture dyes, rubber, and insecticides; [ACGIH]

Comments

Listed in a table of "Industrial Chemicals for Which Methemoglobin Formation is the Principal Cause of Toxicity"; liver injury seen in subchronic animal studies; [ACGIH] Can induce methemoglobinemia; May cause skin sensitization; [ICSC]

Exposure Assessment
BEI

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Skin Designation (ACGIH)

Yes

TLV (ACGIH)

0.64 mg/m3

PEL (OSHA)

1 mg/m3

IDLH (NIOSH)

100 mg/m3

Excerpts from Documentation for IDLHs

Human data: Workers exposed intermittently for 0.5 to 1 hour over many months to concentrations ranging from 7 to 400 mg/m3 (average of 90 mg/m3) had only vague complaints of tiredness, loss of appetite, headache, and afternoon fatigue [Watrous and Schultz 1950]. Because of the strong and disagreeable odor, these workers voluntarily wore respiratory protection when exposed to the higher concentrations [Watrous and Schultz 1950].

Vapor Pressure

0.09 mm Hg

Lethal Concentration

LCLo (rat) = 16,100 mg/m3/4H

Explanatory Notes

Flash point = 127 deg C;

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Skin Sensitizer

Yes

Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Primary

IARC Carcinogen

Not Classifiable

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: