Agent Name

Prothoate

CAS Number

2275-18-5

Formula

C9-H20-N-O3-P-S2

Major Category

Pesticides

Synonyms

2-Diethoxyphosphinothioylthio-N-isopropylacetamide; AC 18682; Acetamide, N-isopropyl-2-mercapto-, S-ester with O,O-diethyl phosphorodithioate; American Cyanamid 18682; EI 18682; ENT 24,652; FAC; FAC (pesticide); FAC 20; FAK 40; Fostion; Isopropyl diethyldithiophosphorylacetamide; L 343; N-Monoisopropylamide of O,O-diethyldithiophosphorylacetic acid; O,O-Diethyl S-(2-((1-methylethyl)amino)-2-oxoethyl) phosphorodithioate (9CI); O,O-Diethyl S-(N-isopropylcarbamoylmethyl) dithiophosphate; O,O-Diethyl S-(N-isopropylcarbamoylmethyl) phosphorodithioate; O,O-Diethyl S-isopropylcarbamoylmethyl phosphorodithioate; O,O-Diethyl phosphorodithioate S-ester with N-isopropyl-2-mercaptoacetamide (8CI); O,O-Diethyldithiophosphorylacetic acid, N-monoisopropylamide; Oleofac; Phosphorodithioic acid, O,O-diethyl S-(2-((1-methylethyl)amino)-2-oxoethyl) ester; Phosphorodithioic acid, O,O-diethyl ester, S-ester with N-isopropyl-2-mercaptoacetamide; Prothoat; Protoat (Hungarian); Telefos; Trimethoate; [ChemIDplus] UN2783

Category

Organophosphate Insecticides

Description

Colorless to yellow solid with an odor of camphor; mp = 28.5 deg C; Technical product: Amber to yellow semi-solid; [HSDB]

Sources/Uses

Used as systemic acaricide and insecticide; Likely discontinued for pesticide use worldwide; [HSDB]

Comments

May cause death or permanent injury from exposure during normal use; A cholinesterase inhibitor that may cause nervous system damage and liver injury; [HSDB] Extremely toxic cholinesterase inhibitor; [CAMEO]

Exposure Assessment
BEI

Cholinesterase activity in red cells = 70% of individual's baseline, sample time discretionary; [ACGIH]

Vapor Pressure

9.75E-5 mm Hg

Lethal Concentration

LC50 (rat) = 165 mg/m3/4h

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Organophosphorus pesticide, solid, toxic."

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Other Poison

Organophosphate

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: