Agent Name

Trimethoxysilane

CAS Number

2487-90-3

Formula

C3-H10-O3-Si

Major Category

Metals

Synonyms

Silane, trimethoxy-; Trimethoxy silane; [ChemIDplus] UN9269

Category

Metalloid Compounds (Silicon)

Description

A colorless liquid; [CAMEO]

Sources/Uses

Used to make organic coupling agents (adhesion promoters) in the plastics industry; [HSDB]

Comments

Vapor can cause blindness; [HSDB] Eye instillation in animal experiments caused iritis and corneal injury with complete healing in 7-10 days; All rats that died after inhalation exposure showed severe lung congestion and hemorrhage; Workers complain of lacrimation and disturbance of vision; [AIHA] Highly toxic by ingestion, inhalation, and skin absorption; May cause severe burns; [CAMEO] May decompose on exposure to moisture; A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Can cause blindness; Inhalation may cause chemical pneumonitis and pulmonary edema; [MSDSonline] See "Methyl silicate."

Exposure Assessment
TIH

Yes

WEEL

0.05 ppm

Vapor Pressure

76 mm Hg

Lethal Concentration

LC50 (rat) = 42 ppm/4h

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Lacrimator

Yes

Toxic Pneumonitis

Yes

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: