Agent Name

Trimethylthiourea

CAS Number

2489-77-2

Formula

C4-H10-N2-S

Major Category

Nitrogen Compounds

Synonyms

1,1,3-Trimethyl-2-thiourea; 1,1,3-Trimethylthiourea; 1,3,3-Trimethylthiourea; N,N,N'-Trimethylthiourea; Thiate E; Thiourea, trimethyl-; Urea, 1,1,3-trimethyl-2-thio-; Thiourea, N,N,N'-trimethyl-; Trimethyl-2-thiourea; [ChemIDplus]

Category

Thiourea Compounds

Description

Solid; [HSDB] Off-white crystals; [Maybridge MSDS]

Sources/Uses

Used as a curing agent for chloroprene/neoprene rubbers and epichlorohydrin elastomers; [HSDB]

Comments

No evidence of carcinogenicity in mice or male rats, but follicular cell carcinomas of the thyroid were observed in female rats in a 77 week feeding study; [NTP] Causes thyroid hypofunction and changes in thyroid weight in seven day continuous oral study of mice at 210 mg/kg; [RTECS] An irritant; [Maybridge MSDS]

Reference Link

Occupational allergic contact dermatitis caused by... [Contact Dermatitis. 1994] - PubMed result

Exposure Assessment
Vapor Pressure

3 mm Hg

Adverse Effects
Skin Sensitizer

Yes

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: