Agent Name

Trimethyltin chloride

CAS Number

1066-45-1

Formula

C3-H9-Cl-Sn

Major Category

Metals

Synonyms

Chlorotrimethylstannane; Chlorotrimethyltin; M&T Chemicals 1222-45; Stannane, chlorotrimethyl-; Stannylium, trimethyl-, chloride; Tin(1+), trimethyl-, chloride; Trimethylchlorostannane; Trimethylchlorotin; Trimethylstannyl chloride; [ChemIDplus] UN3146

Category

Tin Compounds, Organic

Description

Colorless solid; mp = 37.5 deg C; [HSDB] White crystalline solid; [MSDSonline]

Sources/Uses

A byproduct of methyltin manufacture; Used as an experimental pesticide; [HSDB]

Comments

In 1981, six employees in a chemical firm were exposed to trimethyltin chloride while working at the access opening of the reactor. All patients were hospitalized, and one patient died 10 days after the accident. Patients had headache, tiredness, hearing loss, disorientation, and other neurological symptoms. [HSDB] Of the trialkyltins, triethyltin and trimethytin are the most toxic. [ACGIH] An irritant; Can be absorbed through skin; [MSDSonline] See "Tin, organic compounds."

Exposure Assessment
Skin Designation (ACGIH)

Yes

TLV (ACGIH)

0.1 mg/m3, as Sn

STEL (ACGIH)

0.2 mg/m3, as Sn

PEL (OSHA)

0.1 mg/m3, as Sn

MAK

0.005 mg/m3(can also occur as vapor and aerosol), 0.1 mg/m3, inhalable fraction, as Sn

IDLH (NIOSH)

25 mg/m3, as Sn

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Organotin compound, solid, n.o.s." Organic tin compounds have a "skin" designation and are classified as "A4" (Not classifiable as human carcinogen); [ACGIH]

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Hepatotoxin

Hepatotoxin, Secondary

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: