Agent Name

Triphenyl phosphite

CAS Number

101-02-0

Formula

C18-H15-O3-P

Major Category

Other Classes

Synonyms

ADK Stab TPP; Advance TPP; EFED; JP 360; Mellite 310; P 36; P 36 (stabilizer); Phenyl phosphite; Phosclere T 36; Phosphorous acid, triphenyl ester; Stabilizer P 36; Sumilizer TPP-R; Sumilizer TTP-R; TP 1 (plasticizer); TPP; TPP (VAN); TPP (plasticizer); Trifenoxyfosfin [Czech]; Trifenylfosfit [Czech]; Triphenoxyphosphine; Tris(phenoxy)phosphine; Weston TPP; [ChemIDplus]

Category

Phosphite Compounds

Description

Colorless to pale yellow solid or oily liquid; mp = 22-25 deg C; [ICSC] Pleasant odor; [HSDB] Off-white or yellow low melting solid; mp = 22-24 deg C; [MSDSonline]

Sources/Uses

Used as a stabilizer/antioxidant (rubber and plastics industries), metal scavenger, epoxy resin diluent, and insecticide synergist; [HSDB] Used as a reducing agent and in paints, lacquers, and varnishes; [IUCLID]

Comments

Reacts with water; A skin, eye, and respiratory tract irritant; May cause skin sensitization; High concentrations may cause nervous system effects; [ICSC] An eye and severe skin irritant; A mild sensitizer; Emergency treatment: "TOCP and related agents"; Following exposure to >6-7 mg/kg of TOCP, patients have acute GI symptoms of vomiting, diarrhea and abdominal pain; After a delay of 8-35 days, patients develop peripheral neuropathy (flaccid paralysis) that resolves over the next 2-3 months in some patients; Some patients remain permanently paralyzed; [HSDB] Causes flaccid paralysis in rats after subcutaneous doses >2000 mg/kg; [RTECS] A skin irritant; [CAMEO] A skin and eye irritant; [eChemPortal: ESIS] An irritant; Harmful if swallowed; Toxic to aquatic organisms; [MSDSonline] See "Triorthocresyl phosphate."

Exposure Assessment
Lethal Concentration

LC (rat) > 6,700 mg/m3/4h

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Processes

Industrial Processes with risk of exposure: