Agent Name

Cyclohexanol

CAS Number

108-93-0

Formula

C6-H12-O

Major Category

Other Classes

Synonyms

1-Cyclohexanol; Adronal; Adronol; Anol; Cicloesanolo [Italian]; Cyclohexanol; Cyclohexanone cyclohexanol mixture; Cyclohexyl alcohol; Cykloheksanol [Polish]; Hexahydrophenol; Hexalin; Hydralin; Hydrophenol; Hydroxycyclohexane; Naxol; Phenol, hexahydro-; [ChemIDplus] UN1993

Category

Alcohols and Polyols, Other

Description

Sticky solid or colorless to light-yellow liquid (above 77 degrees F) with a camphor-like odor; [NIOSH]

Sources/Uses

Used in the production of nylon, paints, plastics, detergents, textiles, and pesticides; [ACGIH]

Comments

Liquid or solid form causes first degree burns on short exposure; [CHRIS] Skin absorption and narcosis seen in acute animal studies; [ACGIH] A skin, eye, and respiratory tract irritant; Inhalation of high concentrations may cause CNS effects; [ICSC] Causes liver and kidney injury in high-dose animal studies; [HSDB]

Exposure Assessment
BEI

Screen for 1,2-Cyclohexandiol (with hydrolysis) in urine at end of shift at end of workweek;Screen for Cyclohexanol (with hydrolysis) in urine at end of shift;

Skin Designation (ACGIH)

Yes

TLV (ACGIH)

50 ppm

PEL (OSHA)

50 ppm

IDLH (NIOSH)

400 ppm

Excerpts from Documentation for IDLHs

Human data: The estimated acceptable concentration for 8 hours was reported in volunteers to be less than 100 ppm [Nelson et al. 1943].

Vapor Pressure

0.8 mm Hg

Odor Threshold Low

0.05 ppm

Odor Threshold High

0.15 ppm

Lethal Concentration

LC (rat) > 6,500 mg/m3/1h (inhalation)

Explanatory Notes

Detection odor threshold from AIHA (mean = 0.16 ppm); Flash point = 63 deg C;

Half Life

No reports found; [TDR, p. 430]

Reference Link

ICSC: Cyclohexanol

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: