Agent Name

1,2-Diphenylhydrazine

CAS Number

122-66-7

Formula

C12-H12-N2

Major Category

Nitrogen Compounds

Synonyms

(sym)-Diphenylhydrazine; 1,1'-Hydrazodibenzene; Benzene, 1,1'-hydrazobis-; Benzene, hydrazodi-; Hydrazobenzen [Czech]; Hydrazobenzene; N,N'-Bianiline; N,N'-Diphenylhydrazine; Symmetrical diphenyl hydrazine; 1,2-Diphenylhydrazine (9CI); Hydrazine, 1,2-diphenyl-; [ChemIDplus]

Category

Hydrazines

Description

Orange powder or a bright orange crystalline solid; [CAMEO]

Sources/Uses

Used in the past in the United States to produce benzidine; the last manufacturer of benzidine-based dyes in the U.S. ceased production in 1988; Used as an intermediate in the pharmaceutical industry to produce phenylbutazone and sulfinpyrazone; [ATSDR ToxProfiles]

Comments

"1,2-Diphenylhydrazine oxidizes rapidly in the environment under aerobic conditions, with a half-life in water as short as 15 minutes. . . . it is possible that 1,2-diphenylhydrazine may cause methemoglobin in humans. However this would occur only if sufficient aniline were formed rapidly enough to exceed the capacity of methemoglobin reductase to reduce methemoglobin." Hepatic effects have been observed in high-dose animal experiments. [ATSDR ToxProfiles] See "Phenylhydrazine."

Exposure Assessment
Vapor Pressure

0.00044 mm Hg

Reference Link

ATSDR- ToxFAQs - 1,2-Diphenylhydrazine

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

NTP Carcinogen

Anticipated Human Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Other Information

No other related information on this agent was found.