Agent Name

4-Nitrophenol

CAS Number

100-02-7

Formula

C6-H5-N-O3

Major Category

Nitrogen Compounds

Synonyms

4-Hydroxynitrobenzene; 4-Nitrofenol [Dutch]; 4-Nitrophenol; Niphen; PNP; Paranitrofenol [Dutch]; Paranitrofenolo [Italian]; Paranitrophenol; Paranitrophenol [French,German]; Phenol, 4-nitro-; Phenol, p-nitro-; p-Hydroxynitrobenzene; p-Nitrofenol [Czech]; p-Nitrophenol; [ChemIDplus] UN1663

Category

Nitrophenols

Description

Colorless to slightly yellow crystals; [HSDB]

Sources/Uses

Used as an intermediate for insecticides, fungicides, bactericides, and dyes; used as a leather treatment agent; [HSDB] Used to produce dyes, paints, rubber chemicals, and fungicides; [ATSDR ToxProfiles]

Comments

Methemoglobinemia has been reported. [HSDB] 4-Nitrophenol is more toxic than 2-nitrophenol in animals. Rats exposed to 2-nitrophenol at 112 mg/m3 for 2 weeks develop methemoglobinemia. No effect after dust exposures of 30 mg/m3 for 3-6 hours/day, 5 days a week for 4 weeks; [ATSDR ToxProfiles] A skin, eye, and respiratory tract irritant; May cause yellow stains on the skin; Can induce methemoglobinemia; May cause skin sensitization; [ICSC]

Reference Link

EPA Pesticide Fact Sheet: Paranitrophenol - 1998

Exposure Assessment
Vapor Pressure

9.79E-5 mm Hg

Explanatory Notes

Flash point = 377 deg F;

Reference Link

ATSDR - ToxFAQs - Nitrophenols

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Skin Sensitizer

Yes

Methemoglobinemia

Methemoglobinemia, Secondary

Anemia

Anemia, Hemolytic

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Health Studies

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Diseases

Occupational diseases associated with exposure to this agent:

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