Agent Name

Dicyclohexylcarbodiimide

CAS Number

538-75-0

Formula

C13-H22-N2

Major Category

Nitrogen Compounds

Synonyms

1,3-Dicyclohexylcarbodiimide; Bis(cyclohexyl)carbodiimide; Carbodicyclohexylimide; DCC; DCCD; DCCI; N,N'-Dicyclohexylcarbodiimide; N,N'-Methanetetraylbiscyclohexaamine; Carbodiimide, dicyclohexyl-; Cyclohexaamine, N,N'-methanetetraylbis- (9CI); Cyclohexanamine, N,N'-methanetetraylbis-; [ChemIDplus]

Category

Other Nitrogen Compounds

Description

White solid with a sweet odor; [Hawley] White melt; mp = 33-36 deg C; [MSDSonline]

Sources/Uses

Used in chemical synthesis; [Hawley] Used as a coupling reagent in peptide chemistry; [Kanerva, p. 1781]

Comments

A skin, eye, and respiratory tract irritant; High concentrations can be corrosive and very damaging to tissue; [CAMEO] Contact allergen; [Merck Index] An irritant; May cause serious eye injury; May cause skin sensitization; Can be absorbed through skin; Effects in high-dose animal studies include convulsions; [MSDSonline] Danger of skin sensitization; [MAK]

Reference Link

Contact allergy to dicyclohexyl carbodiimide and d... [Contact Dermatitis. 1995] - PubMed result

Exposure Assessment
Lethal Concentration

LC50 (rat) = 159 mg/m3/6h

Explanatory Notes

Flash Point > 235 deg F; [CAMEO]

Adverse Effects
Skin Sensitizer

Yes

Neurotoxin

Other CNS Neurotoxin

Links to Other NLM Databases
Toxicity Information

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Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: