Agent Name

1-Methoxy-2-propyl acetate

Alternative Name

PGMA

CAS Number

108-65-6

Formula

C6-H12-O3

Major Category

Solvents

Synonyms

1-Methoxy-2-acetoxypropane; 1-Methoxy-2-propanol acetate; 2-Acetoxy-1-methoxypropane; Acetic acid, 2-methoxy-1-methylethyl ester; Dowanol (R) PMA glycol ether acetate; PGMEA; Propylene glycol monomethyl ether acetate; Propyleneglycol monomethyl ether acetate; 2-Methoxy-1-methylethyl acetate; 2-Propanol, 1-methoxy-, 2-acetate; 2-Propanol, 1-methoxy-, acetate; [ChemIDplus] PGMA; [ECHA]

Category

Glycol Ethers (P Series)

Description

Colorless, hygroscopic liquid, with a characteristic odor; [ICSC]

Sources/Uses

Used as a solvent for paints, inks, lacquers, varnishes, cleaners, coatings, ink-removers, and pesticides; [eChemPortal: SIDSUNEP] Used in photoresist formulations in the semiconductor industry; Also used in solvents for degreasing circuit boards and in food contact applications; [CHEMINFO]

Comments

An eye and respiratory tract irritant; Inhalation of high concentrations can cause CNS depression; [ICSC] Silk-screen printers were exposed to about 20 ppm; PGMA is not tolerated by workers at concentrations >100 ppm because of objectionable odor and lacrimation. [AIHA] An irritant; [MSDSonline]

Exposure Assessment
MAK

50 ppm

WEEL

50 ppm

Vapor Pressure

3.92 mm Hg

Lethal Concentration

LC50 (rat) > 5,320 ppm/4h

Explanatory Notes

Flash point = 42 deg C; [ICSC] The ERPG levels apply to both the alpha isomer (108-65-6) and the beta isomer (70657-70-4); [AIHA]

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Lacrimator

Yes

Neurotoxin

CNS Solvent Syndrome

Links to Other NLM Databases
Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: