Agent Name

Methyl isopropyl ketone

CAS Number

563-80-4

Formula

C5-H10-O

Major Category

Solvents

Synonyms

2-Acetyl propane; 2-Acetylpropane; 2-Methyl-3-butanone; 3-Methyl-2-butanone; Isopropyl methyl ketone; Ketone, isopropyl methyl; MIPK; Methyl butanone-2; Methyl isopropyl ketone; Methylbutanone (VAN); 2-Butanone, 3-methyl-; 3-Methylbutanone; 3-Methylbutan-2-one; [ChemIDplus] UN2397

Category

Ketones (<C12)

Description

Colorless liquid with an acetone-like odor; [Merck Index]

Sources/Uses

A pyrolysis product from hot gas welding of PVC plastic; [ACGIH]

Comments

A skin, eye, and respiratory tract irritant; Inhalation of high concentrations can cause CNS depression; [ICSC] An irritant; [MSDSonline] Causes narcosis in experimental animals fed high doses by oral gavage; TLV Basis is toxicity to embryo, fetus, and newborn; [ACGIH]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

20 ppm

Vapor Pressure

52.2 mm Hg

Odor Threshold Low

1.9 ppm

Odor Threshold High

4.8 ppm

Lethal Concentration

LCLo (rat) = 5,700 ppm/4h

Explanatory Notes

Flash point = -1 deg C; [ICSC] Odor threshold from CHEMINFO;

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Reproductive Toxin

Yes

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: