Agent Name

Gallium arsenide

CAS Number

1303-00-0

Formula

As-Ga

Major Category

Metals

Synonyms

Gallium monoarsenide; [HSDB]

Category

Arsenic Compounds, Inorganic

Description

Gray crystals or powder; [CAMEO]

Sources/Uses

Used in semiconductor applications; [Merck Index #4347]

Comments

Its toxicity is due to arsenic, and exposed workers can be monitored by urine arsenic levels. [Harrison RJ, State of the Art Reviews: Occupational Medicine, Vol. 1, No. 1, pages 49-58.] Inhalation studies in experimental rats show that both gallium and arsenic are cleared within 14 days after treatment. [Webb DR et al. Pulmonary Clearance and Toxicity of Respirable Gallium Arsenide Particulates. Am Ind Hyg Assoc J. 1987 Jul;48(7):660-7.] Gallium arsenide is "poorly absorbed"; it is excreted primarily in the feces. [Rosenstock, p. 947] Toxic arsenic released when heated to decomposition; [CAMEO] "Metalloid arsenic is generally regarded as nonpoisonous due to its insolubility in water and body fluids." [ATSDR Case Studies: Arsenic Toxicity] Gallium arsenide is classified as a human carcinogen. [IARC] "Because of its ability to cause extensive pulmonary damage in the rat at a level of 10 g/m3 and in the mouse at a level of 100 mg/m3 for particles of 1 m or smaller and because of its ability to cause cancer in female rats (but not male rats), a TLVTWA of 0.3 g/m3 (0.0003 mg/m3) is recommended, with an A3, Confirmed Animal Carcinogen with Unknown Relevance to Humans, designation." [ACGIH] See "Arsenic" and the linked occupational diseases.

Reference Link

Assessment of arsenic exposures and controls in gallium arsenide production

Exposure Assessment
BEI

"Due to the insolubility of gallium arsenide, however, the BEI is not recommended as an index of exposure." [ACGIH]

Skin Designation (ACGIH)

No

Bioaccumulates

Yes

TLV (ACGIH)

0.0003 mg/m3, respirable fraction

Explanatory Notes

NIOSH REL = 15 min ceiling of 0.002 mg/m3; Melting point = 1238 deg C; [Merck Index] Known human carcinogen "as As." [IARC]

Adverse Effects
Anemia

Anemia, Aplastic

Neurotoxin

Sensorimotor Neuropathy

Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

IARC Carcinogen

Known Carcinogen

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Processes

Industrial Processes with risk of exposure: