Agent Name

1,2-Dimethoxyethane

Alternative Name

Monoglyme

CAS Number

110-71-4

Formula

C4-H10-O2

Major Category

Solvents

Synonyms

1,2-Ethanediol dimethyl ether; 2,5-Dioxahexane; Ansul ether 121; DME (glycol ether); Dimethyl Cellosolve; Dimethylcellosolve; EGDME; Ethane, 1,2-dimethoxy-; Ethylene dimethyl ether; Ethylene glycol dimethyl ether; Glycol dimethyl ether; Glyme; Hisolve MMM; Monoethylene glycol dimethyl ether; Monoglyme; [ChemIDplus] UN2252

Category

Glycol Ethers (Glymes)

Description

Colorless liquid; [ICSC] Ether-like odor; [Merck Index] Fully miscible; [MSDSonline]

Sources/Uses

Used as a specialty solvent and reagent; [Merck Index] Used in lithium batteries and industrial coatings; [Reference #1]

Comments

2-Methoxyethanol is a major metaobolite; "The potential health hazard of monoglyme is high based on the results of repeated-dose (blood, thymus, adrenal gland, and testicular degeneration) and developmental (increased fetal death and skeletal effects and decreased fetal body weight) toxicity studies at relatively low doses in animal studies." [Reference #1] Reproductive toxin in animal tests; [ICSC] Labeled as "May impair fertility" and "May cause harm to the unborn child" by EU regulations; [Glycol Ethers Online] Inhalation of vapor may cause dizziness or difficulty breathing; [HSDB] A severe skin and eye irritant; [CAMEO] Reproductive toxin and highly flammable; [MSDSonline] See "GLYCOL ETHERS." See "2-Methoxyethanol."

Reference Link

EPA: Initial Risk-Based Prioritization of HPV Chemicals: Monoglyme

Exposure Assessment
Vapor Pressure

48 mm Hg

Lethal Concentration

LCLo (rat) = 17,096 ppm/6h

Explanatory Notes

Flash point = -2 deg C; [ICSC]

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Reproductive Toxin

Yes

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: