Agent Name

1,6-Diaminohexane

Alternative Name

Hexamethylenediamine

CAS Number

124-09-4

Formula

C6-H16-N2

Major Category

Nitrogen Compounds

Synonyms

Hexamethylenediamine; 1,6-Diamino-n-hexane; 1,6-Diaminohexane; 1,6-Hexamethylenediamine; 1,6-Hexanediamine; 1,6-Hexanediamine (solution); 1,6-Hexylenediamine; HMDA; Hexane, 1,6-diamino-; [ChemIDplus] UN1783(solution); UN2280(solid)

Category

Amines, Aliphatic

Description

Colorless solid; [Hawley] Hygroscopic; [ICSC] Has an ammonia-like or fishy odor; [CHEMINFO] White solid; [MSDSonline]

Sources/Uses

Used as an intermediate to make polyamides with applications in fiber, plastics, polyurethane coatings and adhesives, specialty nylons (monofilaments and inks), and specialty chemicals (biocides, petroleum additives, and phenol purification); [eChemPortal: SIDSUNEP]

Comments

A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Inhalation of high concentrations may cause pulmonary edema; [ICSC] Allergic dermatitis, rhinitis, and asthma were reported in exposed workers. One case of acute hepatitis was reported. In animal experiments, 6 guinea pigs receiving orally 0.02 grams/day for 20-95 days are slowly poisoned and have weight loss, hemolytic anemia, leukopenia, liver damage, and kidney damage; Similar effects are seen in high-dose inhalation studies in rats inhaling 1.25 mg/m3 (0.26 ppm) 4 hours per day for 8 days; [HSDB] Exposed workers complain of skin and respiratory tract irritation; [ACGIH] Does not meet criteria for dermal sensitizer since animal studies were negative and human reports not confirmed; [AIHA] A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; [MSDSonline]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

0.5 ppm

WEEL

1 ppm

Vapor Pressure

0.4 mm Hg

Lethal Concentration

LC (rat) > 200 ppm/4h

Explanatory Notes

Flash point = 85 deg C; [ICSC]

Adverse Effects
Toxic Pneumonitis

Yes

Anemia

Anemia, Hemolytic

Hepatotoxin

Hepatotoxin, Secondary

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Other Information

No other related information on this agent was found.