Agent Name

Tetrachlorophthalic anhydride

CAS Number

117-08-8

Formula

C8-Cl4-O3

Major Category

Plastics & Rubber

Synonyms

1,3-Dioxy-4,5,6,7-tetrachloroisobenzofuran; 1,3-Isobenzofurandione, 4,5,6,7-tetrachloro-; 4,5,6,7-Tetrachloro-1,3-isobenzofurandione; CP 626; Niagathal; Phthalic anhydride, tetrachloro-; Tetrathal; [ChemIDplus] TCPA; [HSDB]

Category

Acid Anhydrides, Cyclic

Description

White odorless solid; [Hawley] Light gray crystalline solid; [Aldrich MSDS]

Sources/Uses

Used as flame retardant in unsaturated polyester resins, polyurethane foams, and surface coatings; also used as a chemical intermediate for pigments, drugs, and plasticizers; [HSDB] May contain hexachlorobenzene as an impurity; [ExPub: CPS&Q]

Comments

Occupational asthma reported in workers manufacturing epoxy resins and plastics; [Malo] Produces the acid on reaction with water; A skin, eye, and respiratory tract irritant; May cause skin sensitization and asthma; [ICSC] Causes kidney and blood changes in gavage studies of rats and lung changes in inhalation studies of rats; [EPA ChAMP] See "ACID ANHYDRIDES."

Reference Link

Occupational asthma due to tetrachlorophthalic anhydride

Exposure Assessment
Lethal Concentration

LC50 (rat) > 3,600 mg/m3/4hr

Adverse Effects
Skin Sensitizer

Yes

Asthma

Yes

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: