Agent Name

Hexahydrophthalic anhydride, all isomers

CAS Number

85-42-7

Formula

C8-H10-O3

Major Category

Plastics & Rubber

Synonyms

1,2-Cyclohexanedicarboxylic acid anhydride; Araldite HT 907; HHPA; Hexahydrophthalic acid anhydride; Lekutherm Hardener H;1,3-Isobenzofurandione, hexahydro-; Cyclohexane-1,2-dicarboxylic anhydride; [ChemIDplus]

Category

Acid Anhydrides, Cyclic

Description

Solid; [ICSC] Glassy solid; [EPA ChAMP] White solid; [Alfa Aesar MSDS]

Sources/Uses

Used as a curing agent for epoxy resins and an intermediate for plasticizers and other chemicals; [Hawley] Used in the chemical, polymers, and paints, lacquers, and varnishes industries; [IUCLID]

Comments

Occupational asthma reported in chemical worker; [Malo] Toxic by inhalation; A strong skin and eye irritant; [Hawley] Slowly decomposed by water forming acids; A skin and severe eye irritant; May cause skin sensitization and asthma; [ICSC] Workers with occupational contact urticaria, rhinitis, and conjunctivitis from airborne exposure had resolution of symptoms after removal from work. [ACGIH] A skin sensitizer in guinea pig maximization test; Hypersensitivity effects of human exposure include asthma, urticaria, contact dermatitis, hemolysis, and late respiratory systemic syndrome; Allergic asthma is reportedly the major hypersensitivity reaction, with most cases apparently of the IgE form; [IUCLID] Several studies have shown respiratory sensitization in humans; Mildly irritating to skin and severely irritating or corrosive to eyes of rabbits; [EPA ChAMP] An irritant that may cause serious eye injury; May cause sensitization by skin contact and inhalation; [Alfa Aesar MSDS] See "ACID ANHYDRIDES." See "Trimellitic anhydride."

Reference Link

Airborne allergic contact urticaria from methylhexahydrophthalic anhydride and hexahydrophthalic anhydride

Exposure Assessment
Skin Designation (ACGIH)

No

Ceiling (ACGIH)

0.005 mg/m3, inhalable fraction and vapor

Vapor Pressure

0.0067 mm Hg

Lethal Concentration

LC50 (rat) > 1,100 mg/m3/4hr

Adverse Effects
Skin Sensitizer

Yes

Asthma

Yes

Anemia

Anemia, Hemolytic

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: