Agent Name

Hexamethylene tetramine

CAS Number




Major Category

Nitrogen Compounds


1,3,5,7-Tetraazaadamantane; 1,3,5,7-Tetraazatricyclo (,7))decane; 1,3,5,7-Tetraazatricyclo( 3,7))decane; 1,3,5,7-Tetraazatricyclo( 37))decane; Aceto HMT; Aminoform; Aminoformaldehyde; Ammoform; Ammonioformaldehyde; Antihydral; Cystamin; Cystogen; Duirexol; Ekagom H; Esametilentetramina [Italian]; Formamine; Formin; Formin (heterocycle); HMT; Herax UTS; Heterin; Hexa (vulcanization accelerator); Hexa-Flo-Pulver; Hexaform; Hexaloids; Hexamethylenamine; Hexamethyleneamine; Hexamethylenetetraamine; Hexamethylenetetramine; Hexamethylenetetraminum; Hexamethylentetramin [German]; Hexamethylentetramine; Hexamethylentetraminum; Hexamine; Hexamine (heterocycle); Hexaminum; Hexasan; Hexasan (VAN); Hexilmethylenamine; Metenamina [INN-Spanish]; Methenamin; Methenamine; Methenaminum [INN-Latin]; Metramine; Nocceler H; Preparation AF; Resotropin; S 4 (heterocycle); Sanceler H; Uramin; Uratrine; Uritone; Urodeine; Urotropin; Urotropine; Vulkacit H 30; Xametrin; [ChemIDplus] UN1328


Amines, Aliphatic


White, crystalline powder or colorless, lustrous crystals; [HSDB]


Used in adhesives, coatings, sealants, and leather preservatives; also used as an anticorrosion agent, antibiotic, dye fixative, chemical stabilizer, and curing agent for formaldehyde resins and rubber; [HSDB] Used as a drug (methenamine) taken by mouth to prevent recurrent urinary tract infections; [Medscape DrugInfo] Used as a hardener for epoxy resins of the bisphenol A type; Used in the tire, rubber, foundry, and phenol-formaldehyde resin industries; Sometimes used in topical drugs and cosmetics; [Kanerva, p. 1811] Used as a formaldehyde releaser for photographic film development. [Kanerva, p. 1054-5]


Decomposes into formaldehyde and can cause occupational asthma and skin sensitization; [ICSC] [Gelfand HH. Respiratory allergy due to chemical compounds encountered in the rubber, lacquer, shellac, and beauty culture industries. J Allergy 34:374-381, 1963. (Not in PubMed)] A skin and eye irritant; A skin sensitizer; May cause asthma; [ICSC] Danger of skin sensitization; [MAK]

Exposure Assessment
Vapor Pressure

0.004 mm Hg

Explanatory Notes

Flash point = 482 deg F;

Reference Link

ICSC: Hexamethylenetetramine

Adverse Effects
Skin Sensitizer




Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information


Chemical Information

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Related Information in HazMap

Occupational diseases associated with exposure to this agent:


Industrial Processes with risk of exposure: