Agent Name

Benzo(a)pyrene

CAS Number

50-32-8

Formula

C20-H12

Major Category

Other Classes

Synonyms

1,2-Benzpyrene; 3,4-BP; 3,4-Benz(a)pyrene; 3,4-Benzo(a)pyrene; 3,4-Benzopirene [Italian]; 3,4-Benzopyrene; 3,4-Benzpyren [German]; 3,4-Benzpyrene; 4,5-Benzpyrene; 6,7-Benzopyrene; B(a)P; BP; BaP; Benz(a)pyrene; Benzo(d,e,f)chrysene; [ChemIDplus]

Category

Polycyclic Aromatic Hydrocarbons

Description

Yellowish solid; Practically insoluble in water; [Merck Index] Yellow crystals; Insoluble in water; [MSDSonline]

Sources/Uses

Used as a research chemical; Not commercially used in the US; [HSDB] Formed during incomplete combustion of organic compounds; Highest levels in aluminum production (up to 100 ug/m3), then roofing and paving (10-20 ug/m3), then lowest exposures: coal liquefaction, coal-tar distillation, wood treatment with creosote, chimney sweeping, and power plants; [Reference #1]

Comments

Benzo(a)pyrene is a biomarker of polycyclic aromatic hydrocarbon (PAH) exposure as occurs in aluminum production and coal gasification, two processes which are carcinogenic to humans (urinary bladder and lung). Exposure to soot in chimney sweeping is a known human carcinogen; Other occupational exposures to PAHs classified as Group 1 are coke production, coal-tar distillation, paving and roofing with coal-tar pitch. [Reference #1] See "POLYCYCLIC AROMATIC HYDROCARBONS." See "Soots," "Coal tar pitch volatiles," "Coke oven emissions," and "Shale oils."

Reference Link

IARC 2012: Benzo(a)pyrene

Exposure Assessment
BEI

1-Hydroxypyrene (1-HP) in urine = 2.5 ug/L at end of shift at end of workweek; (Adjusted for the Pyrene to Benzo(a)pyrene ratio); 3-Hydroxybenzo(a)pyrene (3-HBAP) in urine = Nq at end of shift at end of workweek; [TLVs and BEIs]

PEL (OSHA)

0.2 mg/m3

Vapor Pressure

5.49E-9 mm Hg

Explanatory Notes

"Germ cell mutagens that have shown to increase the mutant frequency in the progeny of exposed mammals." [MAK]

Adverse Effects
Reproductive Toxin

Yes

IARC Carcinogen

Known Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

ACGIH Carcinogen

Suspected Human

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure:

Activities

Activities with risk of exposure: