Agent Name

Maneb

CAS Number

12427-38-2

Formula

C4-H6-N2-S4.Mn

Major Category

Pesticides

Synonyms

Farmaneb; Manesan; Manex; Manzate; Nereb; Newspor; [EXTOXNET]

Category

Dithiocarbamates (Pesticide)

Description

Yellow or brown powder; crystals from alcohol; [HSDB]

Sources/Uses

Used to control potato and tomato blights; [EXTOXNET]

Comments

Classified as "practically nontoxic," maneb has an oral LD50 of greater than 5000 mg/kg in rodents. [EXTOXNET] Allergic contact dermatitis in pesticide handlers is most likely due to maneb, carbofuran, carbaryl, captan, folpet, or captafol. [Marks, p. 312] Danger of skin sensitization; [MAK] The EBCDCs (ethylenebisdithiocarbamates) can cause irritant and allergic contact dermatitis. EBDCs include ferbam, vapam, maneb, mancozeb, zineb, thiram, and ziram. They are also used as rubber accelerators. Ethylene thiourea (ETU), which may contaminate EBCDCs, is carcinogenic and teratogenic in animal experiments. [LaDou, p. 610] ETU is the major metabolite of EBDCs. [Krieger, p. 1690] In high-dose reproductive studies of animals, Maneb causes testicular damage, reduced fertility, and birth defects. [Frazier, p. 230-2] See the agent, "Ethylene thiourea." See "Manganese" and linked occupational diseases.

Reference Link

EXTOXNET PIP - MANEB

Exposure Assessment
TLV (ACGIH)

0.2 mg/m3, as Mn

PEL (OSHA)

Ceiling(OSHA)=5 mg/m3, as Mn

MAK

0.5 mg/m3, inhalable fraction, as Mn

Vapor Pressure

7.5E-8 mm Hg

Explanatory Notes

Maneb is spontaneously combustible. [CAMEO]

Reference Link

ICSC: Maneb

Adverse Effects
Skin Sensitizer

Yes

Neurotoxin

Parkinson's Syndrome

Reproductive Toxin

Yes

IARC Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: