Agent Name

Methyl acetoacetate

CAS Number

105-45-3

Formula

C5-H8-O3

Major Category

Solvents

Synonyms

1-Methoxybutane-1,3-dione; 3-Oxobutanoic acid methyl ester; Acetoacetic acid methyl ester; Acetoacetic methyl ester; Butanoic acid, 3-oxo-, methyl ester; Methyl 3-oxobutanoate; Methyl 3-oxobutyrate; Methyl acetylacetate; Methyl acetylacetonate; Methylacetoacetate; Methylester kyseliny acetoctove [Czech]; [ChemIDplus]

Category

Esters (<C12)

Description

Colorless liquid; [Hawley]

Sources/Uses

Used for organic synthesis and as solvent for cellulose ethers; [HSDB]

Comments

A skin, eye, and respiratory tract irritant; May cause CNS depression; [ICSC] An eye irritant; [CAMEO] A severe eye irritant based on animal studies; [CHEMINFO] An irritant; [MSDSonline]

Exposure Assessment
Vapor Pressure

0.89 mm Hg

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: