Agent Name

Ethyl benzene

CAS Number

100-41-4

Formula

C8-H10

Major Category

Solvents

Synonyms

Ethylbenzene; Ethylbenzol; Phenylethane; Ethylbenzol; [ChemIDplus] UN1175

Category

Aromatic Solvents

Description

Colorless liquid with an aromatic odor; [NIOSH]

Sources/Uses

Used as a solvent and an intermediate in the production of styrene (90%) and other organic chemicals; The general population may be exposed after contact with gasoline, automobile emissions, domestic products containing solvents, and cigarette smoke. [ACGIH] Used as a solvent for resins and coatings; [HSDB]

Comments

Liquid causes first degree burns on short exposure. [CHRIS] Mild irritation but no corneal injury after instillation of 2 drops into rabbit eye; Rats with inhalation exposure to 400 ppm (but not 300 ppm) eight hours per day for five days had increased auditory thresholds and loss of cochlear hair cells; Mild liver toxicity observed in animal inhalation studies; Causes CNS depression in lethal concentration studies; When exposed at 1000 ppm, humans have profuse lacrimation. [ACGIH]

Reference Link

ATSDR - ToxFAQs - Ethylbenzene

Exposure Assessment
BEI

Sum of Mandelic and Phenylglyoxylic acids in urine = 0.15 g/g creatinine at end of shift; Ns (Nonspecific determinants--also present after exposure to styrene;) [TLVs and BEIs]

Skin Designation (ACGIH)

No

TLV (ACGIH)

20 ppm

PEL (OSHA)

100 ppm

MAK

20 ppm

IDLH (NIOSH)

800 ppm

Excerpts from Documentation for IDLHs

Human data: Dizziness was caused in one volunteer after a 5minute exposure to 2,000 ppm [Yant et al. 1930].

Vapor Pressure

9.6 mm Hg

Odor Threshold Low

0.09 ppm

Odor Threshold High

0.6 ppm

RD50

1430 ppm

Lethal Concentration

LCLo (rat) = 4,000 ppm/4H

Explanatory Notes

IDLH = 10% LEL (lower explosive limit); Odor threshold from AIHA; Flash point = 12.8 deg C;

Half Life

Whole body: biphasic with initial of 3.1 hours and slower phase of 25 hours; [TDR, p. 631]

Reference Link

ICSC: Ethylbenzene

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Lacrimator

Yes

Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Dermatotoxin

Skin Burns

IARC Carcinogen

Possible Carcinogen

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure:

Activities

Activities with risk of exposure: