Agent Name

Isobutyl chloroformate

Alternative Name

Isobutyl chlorocarbonate

CAS Number

543-27-1

Formula

C5-H9-Cl-O2

Major Category

Toxic Gases & Vapors

Synonyms

Isobutyl chlorocarbonate; 2-Methylpropyl carbonochloridate; 2-Methylpropyl chloroformate; Chlorocarbonic acid isobutyl ester; Carbonochloridic acid, 2-methylpropyl ester; Formic acid, chloro-, isobutyl ester (8CI); [ChemIDplus] UN2742

Category

Acid Halides

Description

Clear liquid; [Merck Index] Colorless liquid with a pungent odor; [ICSC]

Sources/Uses

Used as A peptide reagent; [Hawley]

Comments

An eye and mucous membrane irritant (vapors); [Merck Index] Corrosive; [Hawley] Reacts with water evolving hydrogen chloride; A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Inhalation may cause pulmonary edema; [ICSC] Highly flammable; Reacts with water exothermically forming hydrogen chloride gas; Highly corrosive to skin, eyes, and mucous membranes; [CAMEO] Corrosive to skin and eyes; [eChemPortal: ERMA] A lachrymator; A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Inhalation may cause chemical pneumonitis; [MSDSonline] See "CHLOROFORMATES."

Exposure Assessment
TIH

Yes

MAK

0.2 ppm

Vapor Pressure

16.5 mm Hg

Adverse Effects
Lacrimator

Yes

Toxic Pneumonitis

Yes

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Toxicity Information

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Chemical Information

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Diseases

Occupational diseases associated with exposure to this agent: