Agent Name

Citrinin

CAS Number

518-75-2

Formula

C13-H14-O5

Major Category

Biological Agents

Synonyms

(3R,4S)-4,6-Dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3H-2-benzopyran-7-carboxylic acid; 3H-2-Benzopyran-7-carboxylic acid, 4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-, (3R-trans)-; 3H-2-Benzopyran-7-carboxylic acid, 4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-, (3R,4S)-; [ChemIDplus]

Category

Mycotoxins

Description

Lemon-yellow solid; [Merck Index]

Sources/Uses

Mycotoxin produced by various species of Penicillium and Aspergillus including strains used to make cheese, sake, and soy sauce; Also found in Monascus species used industrially to make red pigments; Has been identified in foods such as wheat, corn, rice, fermented sausages from Italy, and foods colored with Monascus pigments; [Reference #1]

Comments

Has been associated with yellow rice disease in Japan; Nephrotoxic in experimental animals; [Reference #1] Causes eye irritation in rabbits with conjunctival edema and hyperemia lasting 24 hours post application; Causes gross and histological damage to kidneys in all experimental mammals; Liver necrosis, bile duct proliferation, decreased glycogen in the liver, and increased blood glucose and ALT observed in mice dosed by IP injection; Respiratory effects (stimulation and prostration) noted in animal studies; Benign clear cell adenomas observed in chronic feeding study of rats; [HSDB] A severe skin irritant; Tumorigen, mutagen, and reproductive effector; [RTECS]

Reference Link

PubMed Fulltext: Mycotoxins

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

IARC Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Other Information

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