Agent Name

Acrolein

CAS Number

107-02-8

Formula

C3-H4-O

Major Category

Toxic Gases & Vapors

Synonyms

Acraldehyde; Acrylaldehyde; Acrylic aldehyde; Allyl aldehyde; Propenal; 2-Propenal; [NIOSH]

Category

Other Toxic Gases & Vapors

Description

Colorless or yellow liquid with a piercing, disagreeable odor; [NIOSH]

Sources/Uses

Used in the manufacture of various organic chemical products; also used as a fungicide and pesticide; one of the causes of smoke inhalation injury; acrolein is a combustion product of wood, cellulose, and polyethylene; [Sullivan, p. 1017] Also used as a biocide to kill microorganisms, a fumigant to kill rodents, a leather tanning agent, and histology fixative; [ATSDR Medical Management]

Comments

Corrosive to skin; [Quick CPC] "Tear drawing." May cause pulmonary edema, skin burns, and severe burns to the eyes; [ICSC] Causes first degree burns after short exposure; [CHRIS]

Reference Link

ATSDR Medical Management - Acrolein

Exposure Assessment
Skin Designation (ACGIH)

Yes

TIH

Yes

Ceiling (ACGIH)

0.1 ppm

PEL (OSHA)

0.1 ppm

IDLH (NIOSH)

2 ppm

Excerpts from Documentation for IDLHs

Human data: It has been reported that 5.5 ppm results in intense irritation and marked lacrimation, after 60 seconds [Henderson and Haggard 1943]. Exposures to 1.8 ppm result in slight eye irritation after 1 minute and profuse lacrimation after 4 minutes [NRC 1981]. In volunteers exposed for 5 minutes, concentrations of 2 to 2.3 ppm produced severe irritation [Darley et al. 1960]. A 10-minute exposure at 8 ppm and a 5-minute exposure at 1.2 ppm elicited extreme irritation described as "only just tolerable" [Sim and Pattle 1957].

Vapor Pressure

210 mm Hg

Odor Threshold Low

0.02 ppm

Odor Threshold High

1.8 ppm

RD50

1 ppm

Lethal Concentration

LC50 (rat) = 18 mg/m3/4 hr

Explanatory Notes

Detection odor threshold from AIHA (mean = 1.8 ppm); Odor threshold = between 0.02 and 0.4; [NIOSH OSH Guidelines] The Guide from the Emergency Response Guidebook is for "acrolein, stabilized."

Half Life

No reports found; [TDR, p. 35]

Reference Link

ICSC: Acrolein

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Lacrimator

Yes

Toxic Pneumonitis

Yes

Dermatotoxin

Skin Burns

IARC Carcinogen

Not Classifiable

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

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