Agent Name

Verrucarin A

Alternative Name

Muconomycin A

CAS Number

3148-09-2

Formula

C27-H34-O9

Major Category

Biological Agents

Synonyms

Muconomycin A; 379Y; Antibiotic 379Y; VER A; Spiro(16,18-methano-1H,3H,23H-(1,6,12)trioxacyclooctadecino(3,4-d)(1)benzopyran-17(18H),2'-oxirane)-3,9,14-trione, 4,5,6,7,16,16a,19a,22-octahydro-4-hydroxy-5,16a,21-trimethyl-, stereoisomer; [ChemIDplus]

Category

Mycotoxins

Description

Colorless solid; [Merck Index]

Sources/Uses

A macrocyclic trichothecene mycotoxin produced by Myrothecium, Stachybotrys, and Trichothecium species; [Reference #1] Verrucarins: Macrocyclic trichothecene derivatives produced as secondary metabolites of the soil fungi Myrothecium verrucaria that have antibiotic, antifungal, and cytostatic properties; [Merck Index]

Comments

Trichothecenes often contaminate food and feed, and can cause alimentary hemorrhage and vomiting by ingestion; Skin contact may cause dermatitis; These mycotoxins are highly potent inhibitors of eukaryotic protein synthesis; Human stachybotryotoxicosis has been associated with moldy hay exposure in farm workers; It is now known that Stachybotrys also grows well on various wet building materials such as drywall, wood fiber boards, and even dust-lined air ducts; Other macrocyclic trichothecenes produced by Stachybotrys include satratoxins, roridins, and atranones; [Reference #1] Verrucarins: Extremely toxic; May cause severe skin irritation; Triesters of the sesquiterpene alcohol verrucarol; The closely related roridins are diesters of this alcohol; [Merck Index] A mild skin irritant in guinea pigs; Causes dermatitis, inflammatory effects, and diarrhea in intraperitoneal lethal and toxic-dose studies of mice; Causes leucopenia and changes in other blood cell counts in 50-day intravenous study of monkeys; [RTECS] A mild skin irritant; Fatal by ingestion, inhalation, and skin absorption; [Aldrich MSDS]

Reference Link

PubMed Fulltext: Mycotoxins

Links to Other NLM Databases
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