Agent Name

Penicillic acid

CAS Number

90-65-3

Formula

C8-H10-O4

Major Category

Biological Agents

Synonyms

2,5-Hexadienoic acid, 3-methoxy-5-methyl-4-oxo-; 3-Methoxy-5-methyl-4-oxo-2,5-hexadienoic acid; Kyselina penicilova [Czech]; PA; Penicillic acid; gamma-Keto-beta-methoxy-delta-methylene-delta(sup alpha)-hexenoic acid; 3-Methoxy-5-methyl-4-oxohexa-2,5-dienoic acid; [ChemIDplus]

Category

Mycotoxins

Description

Solid; [Merck Index]

Sources/Uses

A toxic metabolite of Penicillium fungi used to make mold-ripened cheeses; [Reference #1] An antibiotic mycotoxin produced by several Penicillium and Aspergillus fungi; [Merck Index] Exhibits antiviral, antitumor, and cytotoxic activities; [HSDB]

Comments

Mycotoxin with antibiotic and carcinogenic properties; Has been found in tobacco, sausages, and corn; [ChemIDplus] Dermal application to rabbits causes severe edema and necrosis within 2 hours; A single intraperitoneal dose of 90 mg/kg decreases hepatic glutathione levels by 83%; Inhibits sodium-potassium ATPase activity in mice brain and kidney in vitro and in vivo; [HSDB] Causes other liver changes in intraperitoneal lethal-dose study of rats; [RTECS] May cause irritation; Harmful by ingestion; Targets the liver; [Aldrich MSDS]

Reference Link

PubMed Fulltext: Mycotoxins

Exposure Assessment
Vapor Pressure

0.00124 mm Hg

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Dermatotoxin

Skin Burns

IARC Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Other Information

No other related information on this agent was found.