Agent Name

Colistin

CAS Number

1066-17-7

Formula

C45-H85-N13-O10

Major Category

Other Uses

Synonyms

Colimycin; Colisticina; Colistina [INN-Spanish]; Colistine [INN-French]; Colistinum [INN-Latin]; Colomycin; Coly-Mycin; Colymysin S; Kangdisu; Kolimitsin; Polymyxin E; Totazina; [ChemIDplus]

Category

Pharmaceuticals

Sources/Uses

An antibiotic mixture containing mainly colistins A and B; [Merck Index] Acts as a detergent on cell membranes; [ChemIDplus] A polypeptide antibiotic produced by soil microbes; [Hawley]

Comments

A case of occupational asthma was documented. [Reference #1] Given by IM, IV, and inhalation routes for treatment of infections; Significant adverse reactions in patients may include slurred speech, vertigo, weakness, urticaria, GI upset, and nephrotoxicity; [Lexi-ID] Causes convulsions after intraperitoneal injections in mice; [HSDB]

Reference Link

Occupational asthma due to colistin in a pharmaceutical worker.

Adverse Effects
Asthma

Yes

Neurotoxin

Other CNS Neurotoxin

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: