Agent Name

Tumor Necrosis Factor-alpha

CAS Number


Major Category

Biological Agents


Cachectin; Cachectin proteins; Cachectins; Lymphokines and Cytokines, tumor necrosis factor; TNF; TNF Receptor Ligands; TNF alpha; TNF-alpha; TNFalpha; Tumor Necrosis Factors; Tumor necrosis factor; Tumor necrosis factor alpha; [ChemIDplus] Mouse Tumor Necrosis Factor alpha; mTNF alpha; [Cell Signaling MSDS]




Powder; [Cell Signaling MSDS]


"Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta ( LYMPHOTOXIN), but they share TNF RECEPTORS." [ChemIDplus] "Tumor necrosis factor (TNF, cachexin, or cachectin, and formerly known as tumor necrosis factor-alpha or TNF-a) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. It is produced chiefly by activated macrophages (M1), although it can be produced by many other cell types as CD4+ lymphocytes, NK cells and neurons. The primary role of TNF is in the regulation of immune cells." [Wikipedia]


An irritant; [Cell Signaling MSDS]

Links to Other NLM Databases
Toxicity Information


Chemical Information

Search ChemIDplus

Related Information in HazMap
Other Information

No other related information on this agent was found.