Agent Name

Antimony trioxide

CAS Number




Major Category



Antimonious oxide; Antimony Bloom 100A; Antimony Bloom 500A; Antimony White; Antimony oxide (SB203); Antimony oxide (Sb2O3); Antimony sesquioxide; Antimony trioxide; Antimony trioxide production; Antimony(3+) oxide; Antox; Atox B; Atox F; Atox R; Atox S; C.I. 77052; C.I. Pigment White 11; CI 77052; CI Pigment white 11; Chemetron fire shield; Dechlorane A-O; Diantimony trioxide; Exitelite; FireShield H; FireShield LS-FR; Fireshield FSPO 405; Flame Cut 610; Flame Cut 610R; Flameguard VF 59; Flowers of antimony; Microfine A 05; Nyacol A 1510LP; Nyacol A 1530; Octoguard FR 10; Patox C; Patox H; Patox L; Patox M; Patox S; Senarmontite; Stibiox MS; Thermoguard B; Thermoguard L; Thermoguard S; Timonox; Timonox White Star; Twinkling star; Valentinite; Weisspiessglanz; Weisspiessglanz [German]; White star; [ChemIDplus]


Metalloid Compounds (Antimony)


Crystals; [Merck Index]


Antimony trioxide is produced in the US by roasting antimony sulfide ores, resublimating crude antimony oxide, or oxidizing molten antimony metal. [ACGIH] Used to make tartar emetic, paint pigments, stains for iron and copper, enamels, ceramics, glasses, mordants, plastic stabilizers, phosphors, and flame-retardants for canvas, textiles, and plastics; [HSDB] Workers may be exposed manufacturing or using batteries, printing machines, bearings, textiles, and ceramics; [Kanerva, p. 1753]


Epidemiological studies of heavily exposed production workers (antimony sulfide ore smelting) in Great Britain from 1973 and earlier showed increased rates of lung cancer. "At present, U.S. experience on the carcinogenic risk of Sb2O3 production is uninformative. Consequently, Sb2O3 production is given an A2 designation, Suspected Human Carcinogen. No TLV is assigned at this time." A study of an antimony processing plant in the UK in 1963 found average air concentrations of 5 mg/m3. Worker exposure in prior years had greatly exceeded this 1963 average. Three workers with simple pneumoconiosis were found. Their urine antimony levels were 425 to 680 ug/L. A later study in 1967 with improved radiologic techniques found 44 of 262 men with simple pneumoconiosis attributed to antimony exposure. [ACGIH] Smelter workers exposed to antimony trioxide complained of rhinitis, pharyngitis, gastroenteritis, and bronchitis. Cases of septal perforation were reported. [IARC] Antimony trioxide caused allergic contact dermatitis in two ceramics workers. [Kanerva, p. 1753] Antimony is a "hepatotoxic agent." [Zimmerman, p. 4] See "Antimony" and linked occupational diseases.

Reference Link

Contact dermatitis and contact sensitization among... [Contact Dermatitis. 1993] - PubMed result

Exposure Assessment
Skin Designation (ACGIH)



0.5 mg/m3, as Sb


0.5 mg/m3, as Sb


50 mg/m3, as Sb

Explanatory Notes

See "2018 Notice of Intended Changes." [TLVs and BEIs]

Adverse Effects
Skin Sensitizer



Hepatotoxin, Secondary

IARC Carcinogen

Possible Carcinogen

ACGIH Carcinogen

Suspected Human

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information


Chemical Information

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Biomedical References

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Related Information in HazMap

Occupational diseases associated with exposure to this agent:


Industrial Processes with risk of exposure:


Activities with risk of exposure: