Agent Name

2-Naphthol

Alternative Name

beta-Naphthol

CAS Number

135-19-3

Formula

C10-H8-O

Major Category

Other Classes

Synonyms

beta-Naphthol; 2-Hydroxynaphthalene; 2-Naftol [Dutch]; 2-Naftolo [Italian]; 2-Naphthalenol; 2-Naphtol [French]; Azogen Developer A; Betanaphthol; C.I. 37500; C.I. Azoic Coupling Component 1; C.I. Developer 5; Developer A; Developer AMS; Developer BN; Developer sodium; Isonaphthol; NAPHTHOL, BETA; Naphthol B; beta-Hydroxynaphthalene; beta-Monoxynaphthalene; beta-Naftol [Dutch]; beta-Naftolo [Italian]; beta-Naphthol; beta-Naphthyl alcohol; beta-Naphthyl hydroxide; beta-Naphtol [German]; beta-Napthol; [ChemIDplus] UN3077

Category

Naphthols

Description

White solid; Darkens upon aging and exposure to sunlight; [Hawley] Tan chips with a phenol-like odor; [MSDSonline]

Sources/Uses

Used to make dyes, pigments, fungicides, insecticides, pharmaceuticals, and perfumes; Also used as antioxidants for rubber, fats, and oils; as an antiseptic; for lubrication of steam turbines, electric motors, hydraulic equipment, and instruments; and formerly as an anthelmintic; [HSDB] Also used as an additive in electroplating, developer in dyeing and printing of fabrics, in tanneries, and in the paints-lacquers-varnishes industry; [IUCLID]

Comments

A severe eye irritant; May cause skin sensitization; "The substance may have effects on the kidneys, blood and eyes, resulting in kidney impairment, anaemia and lens opacities." [ICSC] Emergency medical treatment: see "Phenol." [HSDB] Causes diarrhea, impaired motility, and corneal opacities in lethal-dose animal studies; A skin sensitizer in guinea pig testing and in a study of workers; Causes liver and kidney injury after repeated administration to animals; [Reference #1] An irritant; May cause injury to eyes; May be absorbed through skin resulting in kidney injury; [MSDSonline]

Reference Link

OECD SIDS: 2-Naphthol - 2002

Exposure Assessment
Odor Threshold Low

0.01 ppm

Odor Threshold High

11.4 ppm

Lethal Concentration

LC50 (rat) = 2,200 mg/m3/4h

Explanatory Notes

Flash point = 152.7 deg C; [Hawley] VP = 9.9 mm Hg at 144 deg C; [HSDB] Odor threshold from HSDB; The Guide in the Emergency Response Guidebook is for "Environmentally hazardous substances, solid, n.o.s."

Adverse Effects
Skin Sensitizer

Yes

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: